Tridecanoin is anticonvulsant, antioxidant, and improves mitochondrial function

Tan, Kah Ni, Carrasco-Pozo, Catalina, McDonald, Tanya S., Puchowicz, Michelle and Borges, Karin (2016) Tridecanoin is anticonvulsant, antioxidant, and improves mitochondrial function. Journal Of Cerebral Blood Flow and Metabolism, 37 6: 2035-2048. doi:10.1177/0271678X16659498

Author Tan, Kah Ni
Carrasco-Pozo, Catalina
McDonald, Tanya S.
Puchowicz, Michelle
Borges, Karin
Title Tridecanoin is anticonvulsant, antioxidant, and improves mitochondrial function
Journal name Journal Of Cerebral Blood Flow and Metabolism   Check publisher's open access policy
ISSN 0271-678X
Publication date 2016-01-01
Sub-type Article (original research)
DOI 10.1177/0271678X16659498
Open Access Status Not yet assessed
Volume 37
Issue 6
Start page 2035
End page 2048
Total pages 14
Place of publication London, United Kingdom
Publisher Sage Publications
Language eng
Formatted abstract
The hypothesis that chronic feeding of the triglycerides of octanoate (trioctanoin) and decanoate (tridecanoin) in “a regular non-ketogenic diet” is anticonvulsant was tested and possible mechanisms of actions were subsequently investigated. Chronic feeding of 35E% of calories from tridecanoin, but not trioctanoin, was reproducibly anticonvulsant in two acute CD1 mouse seizure models. The levels of beta-hydroxybutyrate in plasma and brain were not significantly increased by either treatment relative to control diet. The respective decanoate and octanoate levels are 76 µM and 33 µM in plasma and 1.17 and 2.88 nmol/g in brain. Tridecanoin treatment did not alter the maximal activities of several glycolytic enzymes, suggesting that there is no reduction in glycolysis contributing to anticonvulsant effects. In cultured astrocytes, 200 µM of octanoic and decanoic acids increased basal respiration and ATP turnover, suggesting that both medium chain fatty acids are used as fuel. Only decanoic acid increased mitochondrial proton leak which may reduce oxidative stress. In mitochondria isolated from hippocampal formations, tridecanoin increased respiration linked to ATP synthesis, indicating that mitochondrial metabolic functions are improved. In addition, tridecanoin increased the plasma antioxidant capacity and hippocampal mRNA levels of heme oxygenase 1, and FoxO1.
Keyword Antioxidant
Mitochondrial function
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ
Additional Notes Published online 1 January 2016

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Biomedical Sciences Publications
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Citation counts: TR Web of Science Citation Count  Cited 4 times in Thomson Reuters Web of Science Article | Citations
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Created: Fri, 28 Apr 2017, 14:15:39 EST by Sarah Piper on behalf of Research Strategy and Support (Medicine)