Slc10A4-what do we know about the function of this "secret ligand carrier" protein?

Borges, Karin (2013) Slc10A4-what do we know about the function of this "secret ligand carrier" protein?. Experimental Neurology, 248 258-261. doi:10.1016/j.expneurol.2013.06.019

Author Borges, Karin
Title Slc10A4-what do we know about the function of this "secret ligand carrier" protein?
Journal name Experimental Neurology   Check publisher's open access policy
ISSN 0014-4886
Publication date 2013-10-01
Year available 2013
Sub-type Article (original research)
DOI 10.1016/j.expneurol.2013.06.019
Open Access Status Not yet assessed
Volume 248
Start page 258
End page 261
Total pages 4
Place of publication Maryland Heights, MO, United States
Publisher Academic Press
Language eng
Abstract This commentary discusses the possible functions of a relatively newly described solute carrier protein, Slc10a4, in regards to a recent article by Zelano et al. (2013) published in the January issue of Experimental Neurology, 239, 73-81. Slc10a4 belongs to the sodium-bile acid cotransporter family (Slc10), but does not show plasma membrane transport activity of bile acids and related molecules. It is co-localized with synaptic vesicle transporters for acetylcholine and dopamine. In Slc10a4 lacking mice, Zelano et al. found increased excitability in hippocampal slices and in vivo responses to pilocarpine, but not kainate. These findings are critically examined here. This author speculates on the possible function of Slc10a4, but remains partial about "specific effects of Slc10a4 in cholinergic systems". It is hoped that approaches targeting human SLC10A4 can be discovered for potential clinical use in neurological disorders, such as Alzheimer's and Parkinson's disease, schizophrenia and addiction. Conversely, some side effects are expected due to peripheral Slc10a4 localization in sympathetic and parasympathetic nerves, as well as mast cells.
Keyword Synaptic vesicles
Alzheimer's and Parkinson's disease
Schizophrenia and addiction
Hippocampal Acetylcholine-Release
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Biomedical Sciences Publications
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Citation counts: TR Web of Science Citation Count  Cited 4 times in Thomson Reuters Web of Science Article | Citations
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