Normal and anomalous classification of category exemplars in schizophrenia

Bendall, E. R., McMahon, K. L., Eastburn, M. M., Eadie, K., Durbridge, G. L., Strudwick, M. W., Cowin, G., de Zubicaray, G. I. and Catts, S. V. (2006). Normal and anomalous classification of category exemplars in schizophrenia. In: Australasian Schizophrenia Conference 2006, Fremantle, Australia, (A127-A127). 21st - 23rd August, 2006.

Author Bendall, E. R.
McMahon, K. L.
Eastburn, M. M.
Eadie, K.
Durbridge, G. L.
Strudwick, M. W.
Cowin, G.
de Zubicaray, G. I.
Catts, S. V.
Title of paper Normal and anomalous classification of category exemplars in schizophrenia
Conference name Australasian Schizophrenia Conference 2006
Conference location Fremantle, Australia
Conference dates 21st - 23rd August, 2006
Journal name Australian and New Zealand Journal of Psychiatry   Check publisher's open access policy
Publication Year 2006
Sub-type Published abstract
ISSN 0004-8674
1440-1614
Volume 40
Issue Suppl. 2
Start page A127
End page A127
Total pages 1
Language eng
Abstract/Summary Background Schizophrenia has been associated with semantic memory impairment and previous studies report a difficulty in accessing semantic category exemplars (Moelter et al. 2005 Schizophr Res 78:209–217). The anterior temporal cortex (ATC) has been implicated in the representation of semantic knowledge (Rogers et al. 2004 Psychol Rev 111(1):205–235). We conducted a high-field (4T) fMRI study with the Category Judgment and Substitution Task (CJAST), an analogue of the Hayling test. We hypothesised that differential activation of the temporal lobe would be observed in schizophrenia patients versus controls. Methods Eight schizophrenia patients (7M : 1F) and eight matched controls performed the CJAST, involving a randomised series of 55 common nouns (from five semantic categories) across three conditions: semantic categorisation, anomalous categorisation and word reading. High-resolution 3D T1-weighted images and GE EPI with BOLD contrast and sparse temporal sampling were acquired on a 4T Bruker MedSpec system. Image processing and analyses were performed with SPM2. Results Differential activation in the left ATC was found for anomalous categorisation relative to category judgment, in patients versus controls. Conclusions We examined semantic memory deficits in schizophrenia using a novel fMRI task. Since the ATC corresponds to an area involved in accessing abstract semantic representations (Moelter et al. 2005), these results suggest schizophrenia patients utilise the same neural network as healthy controls, however it is compromised in the patients and the different ATC activity might be attributable to weakening of category-to-category associations.
Subjects CX
Keyword Psychiatry
Q-Index Code CX
Q-Index Status Provisional Code
Institutional Status Non-UQ

 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 0 times in Thomson Reuters Web of Science Article
Google Scholar Search Google Scholar
Created: Tue, 14 Aug 2007, 02:24:33 EST