Equine laminitis induced with oligofructose

Van Eps, A. W. and Pollitt, C. C. (2006) Equine laminitis induced with oligofructose. Equine Veterinary Journal, 38 3: 203-208. doi:10.2746/042516406776866327

Author Van Eps, A. W.
Pollitt, C. C.
Title Equine laminitis induced with oligofructose
Journal name Equine Veterinary Journal   Check publisher's open access policy
ISSN 0425-1644
Publication date 2006-05-01
Year available 2006
Sub-type Article (original research)
DOI 10.2746/042516406776866327
Volume 38
Issue 3
Start page 203
End page 208
Total pages 6
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Son
Language eng
Subject C1
070706 Veterinary Medicine
630107 Minor livestock (e.g. horses, goats, deer)
0707 Veterinary Sciences
Formatted abstract
Reasons for performing study: Experimental induction of equine laminitis with a reliable and clinically relevant model should facilitate understanding of the disease. Successful induction with oligofructose (OF) could link pasture consumption to laminitis.

Objectives: To determine whether alimentary administration of OF induces laminitis.

Methods: Twelve horses were dosed with OF and 6 received a sham (placebo) treatment. Clinical observations were made and blood collected at 4 h intervals over a 48 h study period. Stained sections of the hoof wall lamellae, examined by light microscopy, were graded for laminitis severity.

Results: All horses administered OF, but no sham-treated controls, developed clinical and histological laminitis.

Conclusions and potential relevance: Alimentary overload with OF is a valid induction model for studying the pathogenesis of laminitis. A link is therefore established between field cases of laminitis and pasture fructan content.
Keyword Equine laminitis
Alimentary carbohydrate overload
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

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Created: Tue, 14 Aug 2007, 02:12:33 EST