Prevalence of infection with herpes simplex virus types 1 and 2 in Australia: A nationwide population based survey

Cunningham, A. L., Taylor, R., Taylor, J., Marks, C., Shaw, J. and Mindel, A. (2006) Prevalence of infection with herpes simplex virus types 1 and 2 in Australia: A nationwide population based survey. Sexually Transmitted Infections, 82 2: 164-168. doi:10.1136/sti.2005.016899


Author Cunningham, A. L.
Taylor, R.
Taylor, J.
Marks, C.
Shaw, J.
Mindel, A.
Title Prevalence of infection with herpes simplex virus types 1 and 2 in Australia: A nationwide population based survey
Journal name Sexually Transmitted Infections   Check publisher's open access policy
ISSN 1368-4973
1472-3263
Publication date 2006-01-01
Sub-type Article (original research)
DOI 10.1136/sti.2005.016899
Open Access Status Not yet assessed
Volume 82
Issue 2
Start page 164
End page 168
Total pages 5
Place of publication London, United Kingdom
Publisher BMJ Publishing Group
Language eng
Subject 11 Medical and Health Sciences
1117 Public Health and Health Services
Formatted abstract
Background:
Studies demonstrating previous herpes simplex virus (HSV) type 2 infection as a risk factor for HIV transmission, and the development of a HSV vaccine candidate, have emphasised the need for worldwide population based studies of HSV seroprevalence. The only nationwide seroprevalence studies have been conducted in the United States.

Methods:

An Australia-wide, population based study of HSV-1 and HSV-2 seroprevalence was conducted, using serum and sociodemographic data collected between 1999–2000, for a representative study of risk factors for diabetes in over 11 000 adults. A stratified random sample of 4000 was tested for HSV-2 and 1000 for HSV-1, with sampling and weighting for various demographic factors.

Results:
Seroprevalence of HSV-2 in Australian adults was 12%. Prevalence in women (16%) was twice that in men (8%). Rural populations had a lower prevalence (9%) than metropolitan (13%), and Indigenous had a higher prevalence (18%) than the non-Indigenous populations (12%). The seroprevalence of HSV-1 was 76% with significant differences by age group, sex and Indigenous status.

Conclusion:
These are the first nationwide data to compare with US studies. HSV-2 infection is less common in Australia than the United States, and this will allow planning for combating HIV transmission in high prevalence populations in northern Australia. In addition, the high HSV-1 seroprevalence will be important for future deployment of genital herpes vaccines.
Keyword Infectious Diseases
Sexually-transmitted Infections
Genital Herpes
Homosexual-men
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Public Health Publications
 
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Created: Tue, 14 Aug 2007, 02:08:04 EST