Clinical and laboratory diagnosis of dengue virus infection

Muller, David A., Depelsenaire, Alexandra C. I. and Young, Paul R. (2017) Clinical and laboratory diagnosis of dengue virus infection. Journal of Infectious Diseases, 215 Supp 2: S89-S94. doi:10.1093/infdis/jiw649


Author Muller, David A.
Depelsenaire, Alexandra C. I.
Young, Paul R.
Title Clinical and laboratory diagnosis of dengue virus infection
Journal name Journal of Infectious Diseases   Check publisher's open access policy
ISSN 1537-6613
0022-1899
Publication date 2017-04-10
Year available 2017
Sub-type Article (original research)
DOI 10.1093/infdis/jiw649
Open Access Status Not yet assessed
Volume 215
Issue Supp 2
Start page S89
End page S94
Total pages 6
Place of publication Cary, NC United States
Publisher Oxford University Press
Collection year 2018
Language eng
Abstract Infection with any of the 4 dengue virus serotypes results in a diverse range of symptoms, from mild undifferentiated fever to life-threatening hemorrhagic fever and shock. Given that dengue virus infection elicits such a broad range of clinical symptoms, early and accurate laboratory diagnosis is essential for appropriate patient management. Virus detection and serological conversion have been the main targets of diagnostic assessment for many years, however cross-reactivity of antibody responses among the flaviviruses has been a confounding issue in providing a differential diagnosis. Furthermore, there is no single, definitive diagnostic biomarker that is present across the entire period of patient presentation, particularly in those experiencing a secondary dengue infection. Nevertheless, the development and commercialization of point-of-care combination tests capable of detecting markers of infection present during different stages of infection (viral nonstructural protein 1 and immunoglobulin M) has greatly simplified laboratory-based dengue diagnosis. Despite these advances, significant challenges remain in the clinical management of dengue-infected patients, especially in the absence of reliable biomarkers that provide an effective prognostic indicator of severe disease progression. This review briefly summarizes some of the complexities and issues surrounding clinical dengue diagnosis and the laboratory diagnostic options currently available.
Keyword Dengue virus
Dengue diagnosis
Dengue disease
NS1 antigen capture
Dengue serology
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

 
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Created: Fri, 21 Apr 2017, 11:32:01 EST by Mrs Louise Nimwegen on behalf of School of Chemistry & Molecular Biosciences