CD8+ T cell evasion mandates CD4+ T cell control of chronic gamma-herpesvirus infection

Tan, Cindy S. E., Lawler, Clara and Stevenson, Philip G. (2017) CD8+ T cell evasion mandates CD4+ T cell control of chronic gamma-herpesvirus infection. PLoS Pathogens, 13 4: . doi:10.1371/journal.ppat.1006311


Author Tan, Cindy S. E.
Lawler, Clara
Stevenson, Philip G.
Title CD8+ T cell evasion mandates CD4+ T cell control of chronic gamma-herpesvirus infection
Formatted title
CD8+ T cell evasion mandates CD4+ T cell control of chronic gamma-herpesvirus infection
Journal name PLoS Pathogens   Check publisher's open access policy
ISSN 1553-7366
1553-7374
Publication date 2017-04-10
Sub-type Article (original research)
DOI 10.1371/journal.ppat.1006311
Open Access Status DOI
Volume 13
Issue 4
Total pages 17
Place of publication San Francisco, United States
Publisher Public Library of Science
Collection year 2018
Language eng
Formatted abstract
Gamma-herpesvirus infections are regulated by both CD4+ and CD8+ T cells. However clinical disease occurs mainly in CD4+ T cell-deficient hosts. In CD4+ T cell-deficient mice, CD8+ T cells control acute but not chronic lung infection by Murid Herpesvirus-4 (MuHV-4). We show that acute and chronic lung infections differ in distribution: most acute infection was epithelial, whereas most chronic infection was in myeloid cells. CD8+ T cells controlled epithelial infection, but CD4+ T cells and IFNγ were required to control myeloid cell infection. Disrupting the MuHV-4 K3, which degrades MHC class I heavy chains, increased viral epitope presentation by infected lung alveolar macrophages and allowed CD8+ T cells to prevent disease. Thus, viral CD8+ T cell evasion led to niche-specific immune control, and an essential role for CD4+ T cells in limiting chronic infection.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ
Additional Notes Article number e1006311

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Chemistry and Molecular Biosciences
 
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Created: Fri, 21 Apr 2017, 11:28:46 EST by Mrs Louise Nimwegen on behalf of School of Chemistry & Molecular Biosciences