Bistable front dynamics in a contractile medium: Travelling wave fronts and cortical advection define stable zones of RhoA signaling at epithelial adherens junctions

Priya, Rashmi, Gomez, Guillermo A., Budnar, Srikanth, Acharya, Bipul R., Czirok, Andras, Yap, Alpha S. and Neufeld, Zoltan (2017) Bistable front dynamics in a contractile medium: Travelling wave fronts and cortical advection define stable zones of RhoA signaling at epithelial adherens junctions. Plos Computational Biology, 13 3: . doi:10.1371/journal.pcbi.1005411


Author Priya, Rashmi
Gomez, Guillermo A.
Budnar, Srikanth
Acharya, Bipul R.
Czirok, Andras
Yap, Alpha S.
Neufeld, Zoltan
Title Bistable front dynamics in a contractile medium: Travelling wave fronts and cortical advection define stable zones of RhoA signaling at epithelial adherens junctions
Journal name Plos Computational Biology   Check publisher's open access policy
ISSN 1553-7358
1553-734X
Publication date 2017-03-01
Sub-type Article (original research)
DOI 10.1371/journal.pcbi.1005411
Open Access Status DOI
Volume 13
Issue 3
Total pages 19
Place of publication San Francisco, CA United States
Publisher Public Library of Science
Language eng
Abstract Mechanical coherence of cell layers is essential for epithelia to function as tissue barriers and to control active tissue dynamics during morphogenesis. RhoA signaling at adherens junctions plays a key role in this process by coupling cadherin-based cell-cell adhesion together with actomyosin contractility. Here we propose and analyze a mathematical model representing core interactions involved in the spatial localization of junctional RhoA signaling. We demonstrate how the interplay between biochemical signaling through positive feedback, combined with diffusion on the cell membrane and mechanical forces generated in the cortex, can determine the spatial distribution of RhoA signaling at cell-cell junctions. This dynamical mechanism relies on the balance between a propagating bistable signal that is opposed by an advective flow generated by an actomyosin stress gradient. Experimental observations on the behavior of the system when contractility is inhibited are in qualitative agreement with the predictions of the model.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

 
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