Left ventricular morphology and function in adolescents: Relations to fitness and fatness

Dias, Katrin A. , Spence, Angela L. , Sarma, Satyam , Oxborough, David , Timilsina, Anita S. , Davies, Peter S.W. , Cain, Peter A. , Leong, Gary M. , Charlotte B. Ingul and Coombes, Jeff S. (2017) Left ventricular morphology and function in adolescents: Relations to fitness and fatness. International Journal of Cardiology, . doi:10.1016/j.ijcard.2017.03.047


Author Dias, Katrin A.
Spence, Angela L.
Sarma, Satyam
Oxborough, David
Timilsina, Anita S.
Davies, Peter S.W.
Cain, Peter A.
Leong, Gary M.
Charlotte B. Ingul
Coombes, Jeff S.
Title Left ventricular morphology and function in adolescents: Relations to fitness and fatness
Journal name International Journal of Cardiology   Check publisher's open access policy
ISSN 0167-5273
1874-1754
Publication date 2017-03-11
Year available 2017
Sub-type Article (original research)
DOI 10.1016/j.ijcard.2017.03.047
Open Access Status Not yet assessed
Total pages 7
Place of publication Shannon, Clare Ireland
Publisher Elsevier Ireland
Collection year 2018
Language eng
Formatted abstract
Background: Obesity in childhood predisposes individuals to cardiovascular disease and increased risk of premature
all-cause mortality. The aim of this study was to determine differences in LV morphology and function in
obese and normal-weight adolescents. Furthermore, relationships between LV outcomes, cardiorespiratory
fitness (CRF) and adiposity were explored.
Methods: LV morphology was assessed using magnetic resonance imaging (MRI) in 20 adolescents (11 normalweight
[BMI equivalent to 18 kg/m2–25 kg/m2] and 9 obese [BMI equivalent to ≥30 kg/m2]); 13.3 ± 1.1 years,
45% female, Tanner puberty stage 3 [2–4]) using magnetic resonance imaging (MRI). Global longitudinal strain
(GLS), strain rate (SR) and traditional echocardiographic indices were used to assess LV function. CRF (peak
oxygen consumption), percent body fat (dual-energy x-ray absorptiometry), abdominal adipose tissue (MRI),
and blood biochemistry markers were also evaluated.
Results: Adolescents with obesity showed significantly poorer LV function compared to normal-weight adolescents
(P b 0.05) indicated by higher GLS (+6.29%) and SR in systole (+0.17 s−1), and lower SR in early diastole
(−0.61 s−1), and tissue Doppler velocities (S′ −2.7 cm/s; e′ −2.3 cm/s; A′ −1.1 cm/s). There were no group differences
in LV morphology when indexed to fat free mass (P N 0.05). Moderate to strong associations between myocardial contractility
and relaxation, adiposity, arterial blood pressure and cardiorespiratory fitness were noted (r = 0.49–0.71, P b 0.05).
Conclusion: Obesity in adolescence is associated with altered LV systolic and diastolic function. The notable relationship between LV function, CRF and adiposity highlights the potential utility of multidisciplinary lifestyle interventions to treat diminished LV function in this population.
Keyword Left ventricular mass
Global longitudinal strain
Global longitudinal strain rate
Tissue
Doppler velocities
Adiposity
Cardiorespiratory fitness
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Human Movement and Nutrition Sciences Publications
 
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Created: Thu, 13 Apr 2017, 12:41:44 EST by Sandrine Ducrot on behalf of School of Human Movement and Nutrition Sciences