Early adolescent language development following intrathecal chemotherapy for acute lymphoblastic leukaemia

Lewis, Fiona M. and Bohan, Jaycie K. (2017) Early adolescent language development following intrathecal chemotherapy for acute lymphoblastic leukaemia. International Journal of Speech-Language Pathology, 1-9. doi:10.1080/17549507.2017.1309066


Author Lewis, Fiona M.
Bohan, Jaycie K.
Title Early adolescent language development following intrathecal chemotherapy for acute lymphoblastic leukaemia
Journal name International Journal of Speech-Language Pathology   Check publisher's open access policy
ISSN 1754-9507
1754-9515
Publication date 2017-04-10
Sub-type Article (original research)
DOI 10.1080/17549507.2017.1309066
Open Access Status Not yet assessed
Start page 1
End page 9
Total pages 9
Place of publication Abingdon, Oxfordshire United Kingdom
Publisher Taylor & Francis
Collection year 2018
Formatted abstract
Purpose: Central nervous system (CNS) prophylaxis in the treatment of childhood acute lymphoblastic leukaemia (ALL) is
routinely achieved through intrathecal chemotherapy (ITC). The presence of high level language deficits in older children
who received CNS-directed ITC for ALL in early childhood is yet to be elucidated, with previous research suggesting that
high level language deficits may appear later in ALL survivors’ development at an age when these skills typically emerge.
Method: A test battery covering foundational language skills and higher-order language skills was administered to five
participants (aged 10–15 years) with a history of ITC for ALL. Conversion of each child’s language performance scores to z
scores allowed for clinical interpretation of data across the language areas tested.
Result: Foundational language skills were, in general, of no clinical concern. Three of the five children presented with
clinically impaired language skills in areas including resolving ambiguity, making inferences and composing novel sentences.
Performance variation between the participants and within the individual participants was noted.
Conclusion: Given the importance of early adolescent language abilities to academic and social development in late primary
and secondary schooling, these preliminary findings suggest further research into emerging adolescent language abilities
following ITC for ALL is warranted.
Keyword intrathecal chemotherapy
early adolescent language abilities
chemotherapy late effects
Childhood acute lymphoblastic leukaemia
cognitive-linguistic
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Health and Rehabilitation Sciences Publications
 
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Created: Tue, 11 Apr 2017, 07:28:23 EST by Dr Fiona Lewis on behalf of School of Health & Rehabilitation Sciences