Platform technologies for modern vaccine manufacturing

Charlton Hume, Hayley K. and Lua, Linda H. L. (2017) Platform technologies for modern vaccine manufacturing. Vaccine, . doi:10.1016/j.vaccine.2017.02.069


Author Charlton Hume, Hayley K.
Lua, Linda H. L.
Title Platform technologies for modern vaccine manufacturing
Journal name Vaccine   Check publisher's open access policy
ISSN 1873-2518
0264-410X
Publication date 2017-03-25
Sub-type Article (original research)
DOI 10.1016/j.vaccine.2017.02.069
Open Access Status Not yet assessed
Total pages 6
Place of publication London, United Kingdom
Publisher Elsevier
Collection year 2018
Language eng
Abstract Improved understanding of antigenic components and their interaction with the immune system, as supported by computational tools, permits a sophisticated approach to modern vaccine design. Vaccine platforms provide an effective tool by which strategically designed peptide and protein antigens are modularized to enhance their immunogenicity. These modular vaccine platforms can overcome issues faced by traditional vaccine manufacturing and have the potential to generate safe vaccines, rapidly and at a low cost. This review introduces two promising platforms based on virus-like particle and liposome, and discusses the methodologies and challenges.
Keyword Liposome
Modular
Platform technology
Vaccine design
Virus-like particle
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Australian Institute for Bioengineering and Nanotechnology Publications
 
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