Sex differences in phenotypes of bicuspid aortic valve and aortopathy: insights from a large multicenter, international registry

Kong, William K. F., Regeer, Madelien V., Ng, Arnold C. T., McCormack, Louise, Poh, Kian Keong, Yeo, Tiong Cheng, Shanks, Miriam, Parent, Sarah, Enache, Roxana, Popescu, Bogdan A., Yip, James W., Ma, Lawrence , Kamperidis, Vasileios, Van Der Velde, Enno T., Mertens, Bart, Ajmone Marsan, Nina, Delgado, Victoria and Bax, Jeroen J. (2017) Sex differences in phenotypes of bicuspid aortic valve and aortopathy: insights from a large multicenter, international registry. Circulation: Cardiovascular Imaging, 10 3: . doi:10.1161/CIRCIMAGING.116.005155


Author Kong, William K. F.
Regeer, Madelien V.
Ng, Arnold C. T.
McCormack, Louise
Poh, Kian Keong
Yeo, Tiong Cheng
Shanks, Miriam
Parent, Sarah
Enache, Roxana
Popescu, Bogdan A.
Yip, James W.
Ma, Lawrence
Kamperidis, Vasileios
Van Der Velde, Enno T.
Mertens, Bart
Ajmone Marsan, Nina
Delgado, Victoria
Bax, Jeroen J.
Title Sex differences in phenotypes of bicuspid aortic valve and aortopathy: insights from a large multicenter, international registry
Journal name Circulation: Cardiovascular Imaging   Check publisher's open access policy
ISSN 1942-0080
1941-9651
Publication date 2017-03-01
Sub-type Article (original research)
DOI 10.1161/CIRCIMAGING.116.005155
Open Access Status Not yet assessed
Volume 10
Issue 3
Total pages 8
Place of publication Philadelphia, PA, United States
Publisher Lippincott Williams & Wilkins
Collection year 2018
Language eng
Formatted abstract
Background- This large multicenter, international bicuspid aortic valve (BAV) registry aimed to define the sex differences in prevalence, valve morphology, dysfunction (aortic stenosis/regurgitation), aortopathy, and complications (endocarditis and aortic dissection).

Methods and Results- Demographic, clinical, and echocardiographic data at first presentation of 1992 patients with BAV (71.5% men) were retrospectively analyzed. BAV morphology and valve function were assessed; aortopathy configuration was defined as isolated dilatation of the sinus of Valsalva or sinotubular junction, isolated dilatation of the ascending aorta distal to the sinotubular junction, or diffuse dilatation of the aortic root and ascending aorta. New cases of endocarditis and aortic dissection were recorded. There were no significant sex differences regarding BAV morphology and frequency of normal valve function. When presenting with moderate/severe aortic valve dysfunction, men had more frequent aortic regurgitation than women (33.8% versus 22.2%, P<0.001), whereas women were more likely to have aortic stenosis (34.5% versus 44.1%, P<0.001). Men had more frequently isolated dilatation of the sinus of Valsalva or sinotubular junction (14.2% versus 6.7%, P<0.001) and diffuse dilatation of the aortic root and ascending aorta (16.2% versus 7.3%, P<0.001) than women. Endocarditis (4.5% versus 2.5%, P=0.037) and aortic dissections (0.5% versus 0%, P<0.001) occurred more frequently in men.

Conclusions- Although there is a male predominance among patients with BAV, men with BAV had more frequently moderate/severe aortic regurgitation at first presentation compared with women, whereas women presented more often with moderate/severe aortic stenosis compared with men. Furthermore, men had more frequent aortopathy than women.
Keyword Aortic disease
Aortic valve stenosis
Bicuspid aortic valve
Endocarditis
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
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