Genetic correlation between amyotrophic lateral sclerosis and schizophrenia

McLaughlin, Russell L., Schijven, Dick, Van Rheenen, Wouter, Van Eijk, Kriste R., O'Brien, Margaret, Kahn, Rene S., Ophoff, Roel A., Goris, An, Bradley, Daniel G., Al-Chalabi, Ammar, Van Den Berg, Leonard H., Luykx, Jurjen J., Hardiman, Orla, Veldink, Jan H., Project MinE GWAS Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Catts, Stanley V., Gratten, Jacob, Lee, S. Hong, Wray, Naomi R., Visscher, Peter M. and Mowry, Bryan J. (2017) Genetic correlation between amyotrophic lateral sclerosis and schizophrenia. Nature Communications, 8 . doi:10.1038/ncomms14774

Author McLaughlin, Russell L.
Schijven, Dick
Van Rheenen, Wouter
Van Eijk, Kriste R.
O'Brien, Margaret
Kahn, Rene S.
Ophoff, Roel A.
Goris, An
Bradley, Daniel G.
Al-Chalabi, Ammar
Van Den Berg, Leonard H.
Luykx, Jurjen J.
Hardiman, Orla
Veldink, Jan H.
Project MinE GWAS Consortium
Schizophrenia Working Group of the Psychiatric Genomics Consortium
Catts, Stanley V.
Gratten, Jacob
Lee, S. Hong
Wray, Naomi R.
Visscher, Peter M.
Mowry, Bryan J.
Title Genetic correlation between amyotrophic lateral sclerosis and schizophrenia
Journal name Nature Communications   Check publisher's open access policy
ISSN 2041-1723
Publication date 2017-03-21
Year available 2017
Sub-type Article (original research)
DOI 10.1038/ncomms14774
Open Access Status DOI
Volume 8
Total pages 12
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Subject 1600 Chemistry
1300 Biochemistry, Genetics and Molecular Biology
3100 Physics and Astronomy
Abstract We have previously shown higher-than-expected rates of schizophrenia in relatives of patients with amyotrophic lateral sclerosis (ALS), suggesting an aetiological relationship between the diseases. Here, we investigate the genetic relationship between ALS and schizophrenia using genome-wide association study data from over 100,000 unique individuals. Using linkage disequilibrium score regression, we estimate the genetic correlation between ALS and schizophrenia to be 14.3% (7.05-21.6; P=1 × 10) with schizophrenia polygenic risk scores explaining up to 0.12% of the variance in ALS (P=8.4 × 10). A modest increase in comorbidity of ALS and schizophrenia is expected given these findings (odds ratio 1.08-1.26) but this would require very large studies to observe epidemiologically. We identify five potential novel ALS-associated loci using conditional false discovery rate analysis. It is likely that shared neurobiological mechanisms between these two disorders will engender novel hypotheses in future preclinical and clinical studies.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Queensland Brain Institute Publications
Faculty of Medicine
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