Talarazines A-E: noncytotoxic iron(III) chelators from an Australian mud dauber wasp-associated fungus, Talaromyces sp. (CMB-W045)

Kalansuriya, Pabasara, Quezada, Michelle, Esposito, Breno P. and Capon, Robert J. (2017) Talarazines A-E: noncytotoxic iron(III) chelators from an Australian mud dauber wasp-associated fungus, Talaromyces sp. (CMB-W045). Journal of Natural Products, 80 3: 609-615. doi:10.1021/acs.jnatprod.6b00889


Author Kalansuriya, Pabasara
Quezada, Michelle
Esposito, Breno P.
Capon, Robert J.
Title Talarazines A-E: noncytotoxic iron(III) chelators from an Australian mud dauber wasp-associated fungus, Talaromyces sp. (CMB-W045)
Journal name Journal of Natural Products   Check publisher's open access policy
ISSN 1520-6025
0163-3864
Publication date 2017-03-24
Year available 2017
Sub-type Article (original research)
DOI 10.1021/acs.jnatprod.6b00889
Open Access Status DOI
Volume 80
Issue 3
Start page 609
End page 615
Total pages 7
Place of publication Washington, DC United States
Publisher American Chemical Society
Language eng
Subject 1602 Analytical Chemistry
1313 Molecular Medicine
3004 Pharmacology
3003 Pharmaceutical Science
3002 Drug Discovery
2707 Complementary and alternative medicine
1605 Organic Chemistry
Abstract Chemical analysis of an Australian mud dauber wasp-associated fungus, Talaromyces sp. (CMB-W045), yielded five new coprogen siderophores, talarazines A-E (1-5), together with dimerumic acid (6), desferricoprogen (7), and elutherazine B (8). Structures inclusive of absolute configuration were assigned on the basis of detailed spectroscopic analysis and application of the C Marfey’s method. We report on the noncytotoxic Fe(III) chelation properties of 1-8 and demonstrate that biosynthesis is regulated by available Fe(III) in culture media. We demonstrate a magnetic nanoparticule approach to extracting high-affinity Fe(III) binding metabolites (i.e., 8) from complex extracts.
Formatted abstract
Chemical analysis of an Australian mud dauber wasp-associated fungus, Talaromyces sp. (CMB-W045), yielded five new coprogen siderophores, talarazines A–E (1–5), together with dimerumic acid (6), desferricoprogen (7), and elutherazine B (8). Structures inclusive of absolute configuration were assigned on the basis of detailed spectroscopic analysis and application of the C3 Marfey’s method. We report on the noncytotoxic Fe(III) chelation properties of 1–8 and demonstrate that biosynthesis is regulated by available Fe(III) in culture media. We demonstrate a magnetic nanoparticule approach to extracting high-affinity Fe(III) binding metabolites (i.e., 8) from complex extracts.
Keyword Plant Sciences
Chemistry, Medicinal
Pharmacology & Pharmacy
Plant Sciences
Pharmacology & Pharmacy
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 13/13166-4
DP120100183
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Institute for Molecular Bioscience - Publications
 
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