Negative lymph node count is an independent prognostic factor for patients with rectal cancer who received preoperative radiotherapy

Li, Xinxing, Lu, Hao, Xu, Kai, Wang, Haolu, Liang, Xiaowen and Hu, Zhiqian (2017) Negative lymph node count is an independent prognostic factor for patients with rectal cancer who received preoperative radiotherapy. BMC Cancer, 17 1: . doi:10.1186/s12885-017-3222-8


Author Li, Xinxing
Lu, Hao
Xu, Kai
Wang, Haolu
Liang, Xiaowen
Hu, Zhiqian
Title Negative lymph node count is an independent prognostic factor for patients with rectal cancer who received preoperative radiotherapy
Journal name BMC Cancer   Check publisher's open access policy
ISSN 1471-2407
Publication date 2017-03-28
Sub-type Article (original research)
DOI 10.1186/s12885-017-3222-8
Open Access Status DOI
Volume 17
Issue 1
Total pages 9
Place of publication London, United Kingdom
Publisher BioMed Central
Collection year 2018
Language eng
Formatted abstract
Background: Negative lymph node (NLN) count has been reported to provide more accurate prognostic information than the N stage alone in patients with rectal cancer (RC). Since preoperative radiotherapy (Pre-RT) can significantly affect the LN status, it is unclear whether NLN count still has prognostic value count on survival of patients with RC who received Pre-RT.

Methods: In this study, clinicopathological characteristics, number of positive LNs and survival time were collected from Surveillance, Epidemiology, and End Results Program (SEER)-registered RC patients. Univariate and multivariate Cox proportional hazards models were used to assess the risk factors for survival.

Results: X-tile plots identified 9 (P < 0.001) as the optimal cutoff NLN value to divide the patients into high and low risk subsets in terms of cause specific survival (CSS). NLN count was validated as independently prognostic factor in univariate and multivariate analysis (P < 0.001). Subgroup analysis showed that NLN count was an independently prognostic factor for patients with stage ypII (P = 0.002) and ypIII (P < 0.001).

Conclusions: Our results firmly demonstrated that NLN count provides accurate prognostic information for RC patients with Pre-RT.
Keyword Negative lymph node
Preoperative radiotherapy
Rectal cancer
Survival
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
UQ Diamantina Institute Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 0 times in Thomson Reuters Web of Science Article
Scopus Citation Count Cited 0 times in Scopus Article
Google Scholar Search Google Scholar
Created: Tue, 11 Apr 2017, 00:25:16 EST by Web Cron on behalf of Learning and Research Services (UQ Library)