Hyaluronic acid for post sinus surgery care: systematic review and meta-analysis

Fong, E., Garcia, M., Woods, C. M. and Ooi, E. (2017) Hyaluronic acid for post sinus surgery care: systematic review and meta-analysis. Journal of Laryngology and Otology, 131 S1: S2-S11. doi:10.1017/S0022215116009269


Author Fong, E.
Garcia, M.
Woods, C. M.
Ooi, E.
Title Hyaluronic acid for post sinus surgery care: systematic review and meta-analysis
Journal name Journal of Laryngology and Otology   Check publisher's open access policy
ISSN 1748-5460
0022-2151
Publication date 2017-01-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1017/S0022215116009269
Open Access Status Not yet assessed
Volume 131
Issue S1
Start page S2
End page S11
Total pages 10
Place of publication Cambridge, United Kingdom
Publisher Cambridge University Press
Collection year 2018
Language eng
Formatted abstract
Background: Wound healing after endoscopic sinus surgery may result in adhesion formation. Hyaluronic acid may prevent synechiae development. A systematic review was performed to evaluate the current evidence on the clinical efficacy of hyaluronic acid applied to the nasal cavity after sinus surgery.
Methods: Studies using hyaluronic acid as an adjunct treatment following endoscopic sinus surgery for chronic rhinosinusitis were identified. The primary outcome was adhesion formation rates. A meta-analysis was performed on adhesion event frequency. Secondary outcome measures included other endoscopic findings and patientreported outcomes.
Results: Thirteen studies (501 patients) met the selection criteria. A meta-analysis of adhesion formation frequency on endoscopy demonstrated a lower risk ratio in the hyaluronic acid intervention group (42 out of 283 cases) compared to the control group (81 out of 282) of 0.52 (95 per cent confidence interval = 0.37–0.72). Hyaluronic acid use was not associated with any significant adverse events.
Conclusion: Hyaluronic acid appears to be clinically safe and well tolerated, and may be useful in the early stages after sinus surgery to limit adhesion rate. Further research, including larger randomised controlled trials, is required to evaluate patient- and clinician-reported outcomes of hyaluronic acid post sinus surgery
Keyword Drug therapy
Hyaluronic acid
Quality of life
Rhinitis
Surgery
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
School of Medicine Publications
 
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Created: Sun, 09 Apr 2017, 17:33:43 EST by Eric Fong on behalf of Learning and Research Services (UQ Library)