Non-invasive assessment of the liver using imaging

Thorling (Thompson), Camilla, Wang, Haolu, Liu, Xin, Liang, Xiaowen, Crawford, Darrell H. G. and Roberts, Michael S. (2017). Non-invasive assessment of the liver using imaging. In: Hutchinson, MR and Goldys, EM, Spie Biophotonics Australasia. SPIE BioPhotonics Australasia Conference, Adelaide, SA, Australia, (). 17 - 19 October 2016. doi:10.1117/12.2242883

Author Thorling (Thompson), Camilla
Wang, Haolu
Liu, Xin
Liang, Xiaowen
Crawford, Darrell H. G.
Roberts, Michael S.
Title of paper Non-invasive assessment of the liver using imaging
Conference name SPIE BioPhotonics Australasia Conference
Conference location Adelaide, SA, Australia
Conference dates 17 - 19 October 2016
Convener SPIE
Proceedings title Spie Biophotonics Australasia   Check publisher's open access policy
Journal name Proceedings of SPIE   Check publisher's open access policy
Place of Publication Bellingham, WA, United States
Publisher International Society for Optical Engineering
Publication Year 2017
Year available 2016
Sub-type Fully published paper
DOI 10.1117/12.2242883
Open Access Status Not yet assessed
ISBN 9781510604346
ISSN 1996-756X
Editor Hutchinson, MR
Goldys, EM
Volume 10013
Total pages 5
Language eng
Abstract/Summary Chronic liver disease causes 2,000 deaths in Australia per year and early diagnosis is crucial to avoid progression to cirrhosis and end stage liver disease. There is no ideal method to evaluate liver function. Blood tests and liver biopsies provide spot examinations and are unable to track changes in function quickly. Therefore better techniques are needed. Non-invasive imaging has the potential to extract increased information over a large sampling area, continuously tracking dynamic changes in liver function. This project aimed to study the ability of three imaging techniques, multiphoton and fluorescence lifetime imaging microscopy, infrared thermography and photoacoustic imaging, in measuring liver function. Collagen deposition was obvious in multiphoton and fluorescence lifetime imaging in fibrosis and cirrhosis and comparable to conventional histology. Infrared thermography revealed a significantly increased liver temperature in hepatocellular carcinoma. In addition, multiphoton and fluorescence lifetime imaging and photoacoustic imaging could both track uptake and excretion of indocyanine green in rat liver. These results prove that non-invasive imaging can extract crucial information about the liver continuously over time and has the potential to be translated into clinic in the assessment of liver disease.
Keyword Fluorescence lifetime imaging
Indocyanine green
Infrared thermography
Multiphoton microscopy
Photoacoustic imaging
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Conference Paper
Sub-type: Fully published paper
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