Role of novel type I interferon epsilon in viral infection and mucosal immunity

Xi, Yang, Day, Stephanie L., Jackson, Ronald J. and Ranasinghe, Charani (2012) Role of novel type I interferon epsilon in viral infection and mucosal immunity. Mucosal Immunology, 5 610-622. doi:10.1038/mi.2012.35


Author Xi, Yang
Day, Stephanie L.
Jackson, Ronald J.
Ranasinghe, Charani
Title Role of novel type I interferon epsilon in viral infection and mucosal immunity
Journal name Mucosal Immunology   Check publisher's open access policy
ISSN 1935-3456
1933-0219
Publication date 2012-05-23
Sub-type Article (original research)
DOI 10.1038/mi.2012.35
Open Access Status DOI
Volume 5
Start page 610
End page 622
Total pages 13
Place of publication New York, NY, United States
Publisher Nature Publishing Group
Language eng
Formatted abstract
Intranasal infection with vaccinia virus co-expressing interferon epsilon (VV-HIV-IFN-) was used to evaluate the role of IFN-in mucosal immunity. VV-HIV-IFN-infection induced a rapid VV clearance in lung that correlated with (i) an elevated lung VV-specific CD8+ CD107a+ IFN-γ+ population expressing activation markers CD69/CD103, (ii) enhanced lymphocyte recruitment to lung alveoli with reduced inflammation, and (iii) an heightened functional/cytotoxic CD8+ CD4+ T-cell subset (CD3 hi CCR7 hi CD62L lo) in lung lymph nodes. These responses were different to that observed with intranasal VV-HA-IFN-α 4 or VV-HA-IFN-β infections. When IFN-∈ was used in an intranasal/ intramuscular heterologous HIV prime-boost immunization, elevated HIV-specific effector, but not memory CD8+ T cells responses, were observed in spleen, genito-rectal nodes, and Peyer's patch. Homing marker α4β7 and CCR9 analysis indicated that unlike other type I IFNs, IFN-could promote migration of antigen-specific CD8+ T cells to the gut. Our results indicate that IFN-has a unique role in the mucosae and most likely can be used to control local lung and/or gut infections (i.e., microbicide) such as tuberculosis, HIV-1, or sexually transmitted diseases.
Keyword Type I interferon
IFN-epsilon
Mucosal immunity
Adjuvant Activity
Recombinant Vaccinia Virus
Prime Boost Immunization
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Diamantina Institute Publications
 
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Created: Thu, 06 Apr 2017, 13:03:18 EST by Camilla Xi on behalf of UQ Diamantina Institute