Role of novel type I interferon epsilon in viral infection and mucosal immunity

Xi, Yang, Day, Stephanie L., Jackson, Ronald J. and Ranasinghe, Charani (2012) Role of novel type I interferon epsilon in viral infection and mucosal immunity. Mucosal Immunology, 5 6: 610-622. doi:10.1038/mi.2012.35


Author Xi, Yang
Day, Stephanie L.
Jackson, Ronald J.
Ranasinghe, Charani
Title Role of novel type I interferon epsilon in viral infection and mucosal immunity
Journal name Mucosal Immunology   Check publisher's open access policy
ISSN 1933-0219
Publication date 2012-11-01
Sub-type Article (original research)
DOI 10.1038/mi.2012.35
Open Access Status DOI
Volume 5
Issue 6
Start page 610
End page 622
Total pages 13
Place of publication New York, United States
Publisher Nature Publishing Group
Language eng
Formatted abstract
Intranasal infection with vaccinia virus co-expressing interferon epsilon (VV-HIV-IFN-ε) was used to evaluate the role of IFN-ε in mucosal immunity. VV-HIV- IFN-ε infection induced a rapid VV clearance in lung that correlated with (i) an elevated lung VV-specific CD8+CD107a+IFN-γ+ population expressing activation markers CD69/CD103, (ii) enhanced lymphocyte recruitment to lung alveoli with reduced inflammation, and (iii) an heightened functional/cytotoxic CD8+CD4+ T-cell subset (CD3hiCCR7hiCD62Llo) in lung lymph nodes. These responses were different to that observed with intranasal VV-HA-IFN-α4 or VV-HA-IFN-β infections. When IFN-ε was used in an intranasal/intramuscular heterologous HIV prime-boost immunization, elevated HIV-specific effector, but not memory CD8+T cells responses, were observed in spleen, genito-rectal nodes, and Peyer's patch. Homing marker α4β7 and CCR9 analysis indicated that unlike other type I IFNs, IFN-ε could promote migration of antigen-specific CD8+T cells to the gut. Our results indicate that IFN-ε has a unique role in the mucosae and most likely can be used to control local lung and/or gut infections (i.e., microbicide) such as tuberculosis, HIV-1, or sexually transmitted diseases.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Diamantina Institute Publications
 
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Created: Thu, 06 Apr 2017, 12:28:01 EST by Camilla Xi on behalf of Learning and Research Services (UQ Library)