The duality of macrophage function in Chronic Lymphocytic Leukaemia

Chen, Y. C. E., Mapp, S., Blumenthal, A., Burgess, M. L., Mazzieri, R., Mattarollo, S., Mollee, P., Gill, D. and Saunders, N. A. (2017) The duality of macrophage function in Chronic Lymphocytic Leukaemia. Biochimica et Biophysica Acta (BBA) Reviews on Cancer, 1868 1: 176-182. doi:10.1016/j.bbcan.2017.03.006

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Author Chen, Y. C. E.
Mapp, S.
Blumenthal, A.
Burgess, M. L.
Mazzieri, R.
Mattarollo, S.
Mollee, P.
Gill, D.
Saunders, N. A.
Title The duality of macrophage function in Chronic Lymphocytic Leukaemia
Journal name Biochimica et Biophysica Acta (BBA) Reviews on Cancer   Check publisher's open access policy
ISSN 0304-419X
Publication date 2017-08-01
Year available 2017
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.bbcan.2017.03.006
Open Access Status File (Author Post-print)
Volume 1868
Issue 1
Start page 176
End page 182
Total pages 16
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Language eng
Subject 2730 Oncology
1311 Genetics
1306 Cancer Research
Abstract Chronic lymphocytic leukaemia (CLL) is the most common adult leukaemia and, in some patients, is accompanied by resistance to both chemotherapeutics and immunotherapeutics. In this review we will discuss the role of tumour associated macrophages (TAMs) in promoting CLL cell survival and resistance to immunotherapeutics. In addition, we will discuss mechanisms by which TAMs suppress T-cell mediated antitumour responses. Thus, targeting macrophages could be used to i) reduce the leukaemic burden via the induction of T-cell-mediated antitumour responses, ii) to reduce pro-survival signalling and enhance response to conventional chemotherapeutics or iii) enhance the response to therapeutic antibodies in current clinical use.
Keyword Chronic lymphocytic leukaemia
Tumour associated macrophages (TAMs)
T-cell mediated antitumour responses
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
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Created: Thu, 06 Apr 2017, 11:52:55 EST by Kylie Hengst on behalf of Research Strategy and Support (Medicine)