Roles of WNT, NOTCH, and Hedgehog signaling in the differentiation and function of innate and innate-like lymphocytes

Kling, Jessica C. and Blumenthal, Antje (2017) Roles of WNT, NOTCH, and Hedgehog signaling in the differentiation and function of innate and innate-like lymphocytes. Journal of Leukocyte Biology, 101 4: 827-840. doi:10.1189/jlb.1MR0616-272R


Author Kling, Jessica C.
Blumenthal, Antje
Title Roles of WNT, NOTCH, and Hedgehog signaling in the differentiation and function of innate and innate-like lymphocytes
Journal name Journal of Leukocyte Biology   Check publisher's open access policy
ISSN 0741-5400
1938-3673
Publication date 2017-04-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1189/jlb.1MR0616-272R
Open Access Status Not yet assessed
Volume 101
Issue 4
Start page 827
End page 840
Total pages 14
Place of publication Bethesda, MD, United States
Publisher Federation of American Societies for Experimental Biology
Collection year 2018
Language eng
Abstract Innate lymphoid cells (ILCs) and innate-like lymphocytes have important roles in immune responses in the context of infection, cancer, and autoimmunity. The factors involved in driving the differentiation and function of these cell types remain to be clearly defined. There are several cellular signaling pathways involved in embryogenesis, which continue to function in adult tissue. In particular, the WNT, NOTCH, and Hedgehog signaling pathways are emerging as regulators of hematopoietic cell development and differentiation. This review discusses the currently known roles of WNT, NOTCH, and Hedgehog signaling in the differentiation and function of ILCs and innate-like lymphocytes.
Keyword Innate lymphoid cell
NK cell
NKT cell
γδ T cell
Marginal zone B cell
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
UQ Diamantina Institute Publications
 
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Created: Wed, 05 Apr 2017, 16:44:58 EST by Dr Antje Blumenthal on behalf of Institute for Molecular Bioscience