Infections of virulent and avirulent viruses differentially influenced the expression of dicer-1, ago-1, and microRNAs in Bombus terrestris

Niu, Jinzhi, Meeus, Ivan, DeConinck, Dieter IM, Deforce, Dieter, Etebari, Kayvan, Asgari, Sassan and Smagghe, Guy (2017) Infections of virulent and avirulent viruses differentially influenced the expression of dicer-1, ago-1, and microRNAs in Bombus terrestris. Scientific Reports, 7 45620.1-45620.11. doi:10.1038/srep45620

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Author Niu, Jinzhi
Meeus, Ivan
DeConinck, Dieter IM
Deforce, Dieter
Etebari, Kayvan
Asgari, Sassan
Smagghe, Guy
Title Infections of virulent and avirulent viruses differentially influenced the expression of dicer-1, ago-1, and microRNAs in Bombus terrestris
Formatted title
Infections of virulent and avirulent viruses differentially influenced the expression of dicer-1, ago-1, and microRNAs in Bombus terrestris
Journal name Scientific Reports   Check publisher's open access policy
ISSN 2045-2322
Publication date 2017-04-04
Sub-type Article (original research)
DOI 10.1038/srep45620
Open Access Status DOI
Volume 7
Start page 45620.1
End page 45620.11
Total pages 11
Place of publication London, United Kingdom
Publisher Nature Publishing
Collection year 2018
Language eng
Abstract The microRNA (miRNA) pathway is well established to be involved in host-pathogen interactions. As key insect pollinators, bees are suffering from widely spreading viruses, especially honeybees and bumblebees. In order to better understand bee-virus interaction, we comparatively analyzed the involvement of the bumblebee miRNA pathway upon infection by two different viruses. In our setup, an avirulent infection is induced by slow bee paralysis virus (SBPV) and a virulent infection is induced by Israeli acute paralysis virus (IAPV). Our results showed the increased expressions of dicer-1 and ago-1 upon SBPV infection. There were 17 and 12 bumblebee miRNAs differentially expressed upon SBPV and IAPV infections, respectively. These results may indicate the involvement of the host miRNA pathway in bumblebee-virus interaction. However, silencing of dicer-1 did not influence the genome copy number of SBPV. Target prediction for these differentially expressed miRNAs showed their possible involvement in targeting viral genomic RNA and in the regulation of networks in bumblebee. Our study opens a new insight into bee-virus interaction meditated by host miRNAs.
Keyword Bees
Virus
SBPV
IAPV
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Biological Sciences Publications
 
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Created: Wed, 05 Apr 2017, 11:05:31 EST by Prof Sassan Asgari on behalf of School of Biological Sciences