Development of a human cardiac organoid injury model reveals innate regenerative potential

Voges, Holly K., Mills, Richard J., Elliott, David A., Parton, Robert G., Porrello, Enzo R. and Hudson, James E. (2017) Development of a human cardiac organoid injury model reveals innate regenerative potential. Development, 144 6: 1118-1127. doi:10.1242/dev.143966

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Author Voges, Holly K.
Mills, Richard J.
Elliott, David A.
Parton, Robert G.
Porrello, Enzo R.
Hudson, James E.
Title Development of a human cardiac organoid injury model reveals innate regenerative potential
Journal name Development   Check publisher's open access policy
ISSN 1477-9129
Publication date 2017-03-15
Year available 2017
Sub-type Article (original research)
DOI 10.1242/dev.143966
Open Access Status File (Publisher version)
Volume 144
Issue 6
Start page 1118
End page 1127
Total pages 10
Place of publication Cambridge, United Kingdom
Publisher Company of Biologists
Language eng
Subject 1312 Molecular Biology
1309 Developmental Biology
Abstract The adult human heart possesses a limited regenerative potential following an ischemic event, and undergoes a number of pathological changes in response to injury. Although cardiac regeneration has been documented in zebrafish and neonatal mouse hearts, it is currently unknown whether the immature human heart is capable of undergoing complete regeneration. Combined progress in pluripotent stem cell differentiation and tissue engineering has facilitated the development of human cardiac organoids (hCOs), which resemble fetal heart tissue and can be used to address this important knowledge gap. This study aimed to characterize the regenerative capacity of immature human heart tissue in response to injury. Following cryoinjury with a dry ice probe, hCOs exhibited an endogenous regenerative response with full functional recovery 2 weeks after acute injury. Cardiac functional recovery occurred in the absence of pathological fibrosis or cardiomyocyte hypertrophy. Consistent with regenerative organisms and neonatal human hearts, there was a high basal level of cardiomyocyte proliferation, which may be responsible for the regenerative capacity of the hCOs. This study suggests that immature human heart tissue has an intrinsic capacity to regenerate.
Keyword Cardiac organoids
Cardiac tissue engineering
Injury model
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 501100000925
Institutional Status UQ

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