Animal models for assessing the impact of natural products on the aetiology and metabolic pathophysiology of Type 2 diabetes

Asrafuzzaman, Md., Cao, Yingnan, Afroz, Rizwana, Kamato, Danielle, Gray, Susan and Little, Peter J. (2017) Animal models for assessing the impact of natural products on the aetiology and metabolic pathophysiology of Type 2 diabetes. Biomedicine and Pharmacotherapy, 89 1242-1251. doi:10.1016/j.biopha.2017.03.010


Author Asrafuzzaman, Md.
Cao, Yingnan
Afroz, Rizwana
Kamato, Danielle
Gray, Susan
Little, Peter J.
Title Animal models for assessing the impact of natural products on the aetiology and metabolic pathophysiology of Type 2 diabetes
Journal name Biomedicine and Pharmacotherapy   Check publisher's open access policy
ISSN 1950-6007
0753-3322
Publication date 2017-05-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.biopha.2017.03.010
Open Access Status Not yet assessed
Volume 89
Start page 1242
End page 1251
Total pages 10
Place of publication Cedex, France
Publisher Elsevier Masson
Collection year 2018
Language eng
Abstract Type 2 diabetes mellitus is a complex and heterogeneous disorder which in its most common manifestation arises from insulin resistance and later insulin insufficiency. Type 2 diabetes is characterised by impaired insulin sensitivity and diagnosed as hyperglycaemia. Because of its cardiovascular consequences, Type 2 diabetes represents one of the world's leading causes of mortality and morbidity. Drug discovery and development are required to produce better ways to prevent, treat and manage diabetes and its complications. Diabetes is a human, not an animal disease, so animals do not get Type 2 diabetes. However there are animal models which are variously suitable for the investigation of new agents for the treatment of Type 2 diabetes. In this Review we have examined the various models that are available for the study of natural products with a focus on models (genetic, nutritional and spontaneous) for the metabolic abnormities of diabetes. These models are also relevant to the investigation of Western medicines for the treatment of diabetes. A suitable experimental model plays an important role in drug discovery for translational studies leading to increased understanding of the molecular basis and management of diabetes.
Keyword Animal models
Genetics
Hyperglycaemia
Streptozotocin
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
School of Pharmacy Publications
 
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