Antibacterial nanoparticles based on fluorescent 3-substituted uridine analogue

Reddy, E. Ramanjaneya, Yaseen, Abdul M., Rizvi, Arshad, Deora, Girdhar S., Banerjee, Sharmistha, Sevilimedu, Aarti and Rajadurai, Marina (2017) Antibacterial nanoparticles based on fluorescent 3-substituted uridine analogue. Chemistryselect, 2 1: 557-561. doi:10.1002/slct.201601708


Author Reddy, E. Ramanjaneya
Yaseen, Abdul M.
Rizvi, Arshad
Deora, Girdhar S.
Banerjee, Sharmistha
Sevilimedu, Aarti
Rajadurai, Marina
Title Antibacterial nanoparticles based on fluorescent 3-substituted uridine analogue
Journal name Chemistryselect   Check publisher's open access policy
ISSN 2365-6549
Publication date 2017-01-03
Sub-type Article (original research)
DOI 10.1002/slct.201601708
Open Access Status Not yet assessed
Volume 2
Issue 1
Start page 557
End page 561
Total pages 5
Place of publication Weinheim, Germany
Publisher Wiley - V C H Verlag GmbH & Co. KGaA
Collection year 2018
Language eng
Formatted abstract
With a sudden and rapid increase in the spread of antimicrobial resistance, there is an urgent need for the development of novel antimicrobial therapies. Nanoparticles with antimicrobial activity provide advantages such as improved solubility, permeability, stability and selectivity. In this study, a uridine-scaffold was connected to a pyrene fluorescent unit to obtain novel compound UPy via an economical and straightforward route. Further, fluorescent organic nanoparticles (FONs) were prepared via self assembly of UPy and were found to have antibacterial activity towards Gram positive bacteria. The fluorescent nature of the FONs allowed us to identify a binding partner and propose mechanism of action in vivo. We believe that UPy can be an excellent starting point for the development of novel, potent and selective antimicrobial nanotherapeutics.
Keyword Antibacterial
Fluorescence
Nanoparticles
Nucleoside
Selectivity
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Pharmacy Publications
 
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