Seasonal variation in cervical artery dissection in the Hunter New England region, New South Wales, Australia: a retrospective cohort study

Thomas, Lucy C., Makaroff, Andrew P., Oldmeadow, Chris, Attia, John R. and Levi, Christopher R. (2017) Seasonal variation in cervical artery dissection in the Hunter New England region, New South Wales, Australia: a retrospective cohort study. Manual Therapy, 27 106-111. doi:10.1016/j.math.2016.10.007

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Author Thomas, Lucy C.
Makaroff, Andrew P.
Oldmeadow, Chris
Attia, John R.
Levi, Christopher R.
Title Seasonal variation in cervical artery dissection in the Hunter New England region, New South Wales, Australia: a retrospective cohort study
Journal name Manual Therapy   Check publisher's open access policy
ISSN 1532-2769
1356-689X
Publication date 2017-02-01
Year available 2016
Sub-type Article (original research)
DOI 10.1016/j.math.2016.10.007
Open Access Status Not yet assessed
Volume 27
Start page 106
End page 111
Total pages 6
Place of publication London, United Kingdom
Publisher Churchill Livingstone
Collection year 2018
Language eng
Formatted abstract
Background: Cervical artery dissection (CAD) is a leading cause of ischemic stroke among middle aged adults, yet the aetiology remains poorly understood. There are reports from colder northern hemisphere sites of a seasonal pattern in the incidence of CAD. Seasonality may suggest some transient putative pro-inflammatory mechanism but it is unknown whether this also exists in temperate climates.

Aims: To investigate the seasonal variation in incidence of CAD in the xx Region, Australia, and to compare seasonal incidence and selected clinical features between cases of carotid and vertebral artery dissection.

Methods: This retrospective observational study investigated seasonal variation in CAD from a regional stroke register between 2006 and 2014. Clinical features and site of dissection were dichotomized into autumn-winter and spring-summer groups and compared with Chi2 analysis.

Results: 61 CAD events were identified. A strong trend was identified for CAD to occur more frequently in autumn-winter compared to spring-summer (38, 62.30% vs. 23, 37.70%; p = 0.054). Males were significantly more likely to present with vertebral artery dissection (VAD) than females (27, 73.0% vs 10, 41.7%; p = 0.014). A history of mild trauma was more common in VAD than internal carotid artery dissection (ICAD) (14, 41.2% vs 3, 13.0%; p = 0.023). Cases of VAD were more likely to have had an elevated white cell count than ICAD (16, 47.1% vs 5, 20.8%; p = 0.041).

Conclusions: The findings suggest seasonal variation in the CAD incidence in a temperate region of Australia. Clinicians should be vigilant for CAD or risk of CAD during the colder months.
Keyword Carotid artery
Cervical artery dissection
Risk factors
Vertebral artery
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Health and Rehabilitation Sciences Publications
 
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Created: Fri, 31 Mar 2017, 13:30:06 EST by Anthony Yeates on behalf of Learning and Research Services (UQ Library)