Effectiveness of a cough management algorithm at the transitional phase from acute to chronic cough in Australian children aged <15 years: protocol for a randomised controlled trial

O'Grady, Kerry-Ann F., Grimwood, Keith, Toombs, Maree, Sloots, Theo P., Otim, Michael, Whiley, David, Anderson, Jennie, Rablin, Sheree, Torzillo, Paul J., Buntain, Helen, Connor, Anne, Adsett, Don, Meng Kar, Oon and Chang, Anne B. (2017) Effectiveness of a cough management algorithm at the transitional phase from acute to chronic cough in Australian children aged <15 years: protocol for a randomised controlled trial. BMJ Open, 7 3: . doi:10.1136/bmjopen-2016-013796


Author O'Grady, Kerry-Ann F.
Grimwood, Keith
Toombs, Maree
Sloots, Theo P.
Otim, Michael
Whiley, David
Anderson, Jennie
Rablin, Sheree
Torzillo, Paul J.
Buntain, Helen
Connor, Anne
Adsett, Don
Meng Kar, Oon
Chang, Anne B.
Title Effectiveness of a cough management algorithm at the transitional phase from acute to chronic cough in Australian children aged <15 years: protocol for a randomised controlled trial
Journal name BMJ Open   Check publisher's open access policy
ISSN 2044-6055
Publication date 2017-03-01
Sub-type Article (original research)
DOI 10.1136/bmjopen-2016-013796
Open Access Status DOI
Volume 7
Issue 3
Total pages 12
Place of publication London, United Kingdom
Publisher B M J Group
Collection year 2018
Language eng
Formatted abstract
Introduction: Acute respiratory infections (ARIs) are leading causes of hospitalisation in Australian children and, if recurrent, are associated with increased risk of chronic pulmonary disorders later in life. Chronic (>4â €..weeks) cough in children following ARI is associated with decreased quality-of-life scores and increased health and societal economic costs. We will determine whether a validated evidence-based cough algorithm, initiated when chronic cough is first diagnosed after presentation with ARI, improves clinical outcomes in children compared with usual care.

Methods and analysis: A multicentre, parallel group, open-label, randomised controlled trial, nested within a prospective cohort study in Southeast Queensland, Australia, is underway. 750 children aged <15â €..years will be enrolled and followed weekly for 8â €..weeks after presenting with an ARI with cough. 214 children from this cohort with persistent cough at day 28 will be randomised to either early initiation of a cough management algorithm or usual care (107 per group). Randomisation is stratified by reason for presentation, site and total cough duration at day 28 (<6 and ≥6â €..weeks). Demographic details, risk factors, clinical histories, examination findings, cost-of-illness data, an anterior nasal swab and parent and child exhaled carbon monoxide levels (when age appropriate) are collected at enrolment. Weekly contacts will collect cough status and cost-of-illness data. Additional nasal swabs are collected at days 28 and 56. The primary outcome is time-To-cough resolution. Secondary outcomes include direct and indirect costs of illness and the predictors of chronic cough postpresentation.

Ethics and dissemination: The Children's Health Queensland (HREC/15/QRCH/15) and the Queensland University of Technology University (1500000132) Research Ethics Committees have approved the study. The study will inform best-practice management of cough in children.

Trial registration number: ACTRN12615000132549.
Keyword Children
Chronic cough
Cost effectiveness
Intervention
Randomised controlled trial
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Medicine Publications
 
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