Prefrontal dysconnectivity links to working memory deficit in first-episode schizophrenia

Fang, Xiaojing, Wang, Yulin, Cheng, Luqi, Zhang, Yuanchao, Zhou, Yuan, Wu, Shihao, Huang, Huan, Zou, Jilin, Chen, Cheng, Chen, Jun, Wang, Huiling and Jiang, Tianzi (2017) Prefrontal dysconnectivity links to working memory deficit in first-episode schizophrenia. Brain Imaging and Behavior, 1-10. doi:10.1007/s11682-017-9692-0


Author Fang, Xiaojing
Wang, Yulin
Cheng, Luqi
Zhang, Yuanchao
Zhou, Yuan
Wu, Shihao
Huang, Huan
Zou, Jilin
Chen, Cheng
Chen, Jun
Wang, Huiling
Jiang, Tianzi
Title Prefrontal dysconnectivity links to working memory deficit in first-episode schizophrenia
Journal name Brain Imaging and Behavior   Check publisher's open access policy
ISSN 1931-7565
1931-7557
Publication date 2017-03-13
Sub-type Article (original research)
DOI 10.1007/s11682-017-9692-0
Open Access Status Not yet assessed
Start page 1
End page 10
Total pages 10
Place of publication New York, NY, United States
Publisher Springer New York LLC
Collection year 2018
Language eng
Abstract Working memory (WM) deficit is a core feature of schizophrenia and is characterized by abnormal functional integration in the prefrontal cortex, including the dorsolateral prefrontal cortex (dLPFC), dorsal anterior cingulate cortex (dACC), and ventrolateral prefrontal cortex (vLPFC). However, the specific mechanism by which the abnormal neuronal circuits that involve these brain regions contribute to this deficit is still unclear. Therefore, this study focused on these regions and sought to answer which abnormal causal relationships in these regions can be linked to impaired WM in schizophrenia. We used spectral dynamic causal modeling to estimate directed (effective) connectivity between these regions based on resting-state functional magnetic resonance imaging data from healthy control (HC) subjects and patients with first-episode schizophrenia (FES). By comparing these effective connections in the controls and patients, we found that the effective connectivity from the dACC to the dLPFC and from the right dLPFC to the left vLPFC was weaker in the FES group than in the HC group. Furthermore, these effective connections displayed a positive correlation with WM performance in the HCs. However, in the FES patients, the effective connectivity from the dACC to the dLPFC was not correlated with WM performance, and the effective connectivity from the right dLPFC to the left vLPFC was negatively correlated with WM performance. These results could be explained by an aberrant top-down mechanism of WM processing and provide new evidence for the dysconnectivity hypothesis of schizophrenia.
Keyword Effective connectivity
Resting-state fMRI
Schizophrenia
Spectral dynamic causal modeling
Working memory deficit
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Queensland Brain Institute Publications
 
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Created: Tue, 28 Mar 2017, 00:20:19 EST by Web Cron on behalf of Learning and Research Services (UQ Library)