Transgenerational paternal transmission of acquired traits: stress-induced modification of the sperm regulatory transcriptome and offspring phenotypes

Pang, Terence Y. C., Short, Annabel K., Bredy, Timothy W. and Hannan, Anthony J. (2017) Transgenerational paternal transmission of acquired traits: stress-induced modification of the sperm regulatory transcriptome and offspring phenotypes. Current Opinion in Behavioral Sciences, 14 140-147. doi:10.1016/j.cobeha.2017.02.007


Author Pang, Terence Y. C.
Short, Annabel K.
Bredy, Timothy W.
Hannan, Anthony J.
Title Transgenerational paternal transmission of acquired traits: stress-induced modification of the sperm regulatory transcriptome and offspring phenotypes
Journal name Current Opinion in Behavioral Sciences   Check publisher's open access policy
ISSN 2352-1546
2352-1554
Publication date 2017-04-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.cobeha.2017.02.007
Open Access Status Not yet assessed
Volume 14
Start page 140
End page 147
Total pages 8
Place of publication Amsterdam, Netherlands
Publisher Elsevier BV
Collection year 2018
Language eng
Abstract In recent years, it has become evident that pre-conceptual exposure of males to various environmental factors induces epigenetic changes in sperm, which can mediate the transmission of acquired traits in their offspring. The most thoroughly examined paternal exposures involve stress and elevated corticosterone, which have been shown to modulate offspring phenotypes in a manner that is relevant to predisposition to brain disorders, and psychiatric illness in particular. Recent seminal studies have demonstrated that key epigenetic information transmitted via the paternal germline involves small non-coding (snc) RNA transcripts such as microRNAs. Following fertilisation, these sncRNAs appear to regulate development so as to modify the phenotype of the offspring. Understanding the mechanisms involved in such transgenerational effects may facilitate future screening of human sperm for ‘epigenetic health’ and the tailoring of therapeutic interventions according to genetic and epigenetic contributions to illness.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
Queensland Brain Institute Publications
 
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