Spongian-16-one Diterpenes and their Anatomical Distribution in the Australian Nudibranch Goniobranchus collingwoodi

Forster, Louise C., Winters, Anne E., Cheney, Karen L., Dewapriya, Pradeep, Capon, Robert J. and Garson, Mary J. (2017) Spongian-16-one Diterpenes and their Anatomical Distribution in the Australian Nudibranch Goniobranchus collingwoodi. Journal of Natural Products, 80 3: 670-675. doi:10.1021/acs.jnatprod.6b00936


Author Forster, Louise C.
Winters, Anne E.
Cheney, Karen L.
Dewapriya, Pradeep
Capon, Robert J.
Garson, Mary J.
Title Spongian-16-one Diterpenes and their Anatomical Distribution in the Australian Nudibranch Goniobranchus collingwoodi
Journal name Journal of Natural Products   Check publisher's open access policy
ISSN 0163-3864
1520-6025
Publication date 2017-03-24
Year available 2017
Sub-type Article (original research)
DOI 10.1021/acs.jnatprod.6b00936
Open Access Status Not yet assessed
Volume 80
Issue 3
Start page 670
End page 675
Total pages 6
Place of publication Washington, DC, United States
Publisher American Chemical Society
Language eng
Subject 1602 Analytical Chemistry
1313 Molecular Medicine
3004 Pharmacology
3003 Pharmaceutical Science
3002 Drug Discovery
2707 Complementary and alternative medicine
1605 Organic Chemistry
Abstract Six new (1-6) spongian-16-one analogues have been characterized from the Australian nudibranch species Goniobranchus collingwoodi, along with four known spongian-16-one derivatives. The structures and relative configuration were suggested by spectroscopic analyses informed by molecular modeling. Dissection of animal tissue revealed that the mantle and viscera differ in their terpene composition. Whole body extracts were not toxic to brine shrimp (Artemia sp.), but were unpalatable to palaemon shrimp (Palaemon serenus) at a concentration found within the nudibranch. Individual terpenes were not cytotoxic to human lung (NCIH-460), colorectal (SW620), and liver (HepG2) cancer cells.
Formatted abstract
Six new (1−6) spongian-16-one analogues have been characterized from the Australian nudibranch species Goniobranchus collingwoodi, along with four known spongian-16-one derivatives. The structures and relative configuration were suggested by spectroscopic analyses informed by molecular modeling. Dissection of animal tissue revealed that the mantle and viscera differ in their terpene composition. Whole body extracts were not toxic to brine shrimp (Artemia sp.), but were unpalatable to palaemon shrimp (Palaemon serenus) at a concentration found within the nudibranch. Individual terpenes were not cytotoxic to human lung (NCIH-460), colorectal (SW620), and liver (HepG2) cancer cells.
Keyword Marine Sponges
Oxygenated Diterpenes
Chromodoris
Dendroceratida
Constituents
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID DP110103021
Institutional Status UQ

 
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Created: Mon, 27 Mar 2017, 12:24:22 EST by Gail Walter on behalf of School of Biological Sciences