Plasmodium malariae and P. ovale genomes provide insights into malaria parasite evolution

Rutledge, Gavin G., Bohme, Ulrike, Sanders, Mandy, Rrid, Adam J., Cotton, James A., Maiga-Ascofare, Oumou, Djimde, Abdoulaye A., Apinjoh, Tobias O., Amenga-Etego, Lucas, Manske, Magnus, Barnwell, John W., Renaud, Francois, Ollomo, Benjamin, Prugnolle, Franck, Anstey, Nicholas M., Auburn, Sarah, Price, Ric N., McCarthy, James S., Kwiatkowski, Dominic P., Newbold, Chris I., Berriman, Matthew and Otto, Thomas D. (2017) Plasmodium malariae and P. ovale genomes provide insights into malaria parasite evolution. Nature, 542 7639: 101-104. doi:10.1038/nature21038


Author Rutledge, Gavin G.
Bohme, Ulrike
Sanders, Mandy
Rrid, Adam J.
Cotton, James A.
Maiga-Ascofare, Oumou
Djimde, Abdoulaye A.
Apinjoh, Tobias O.
Amenga-Etego, Lucas
Manske, Magnus
Barnwell, John W.
Renaud, Francois
Ollomo, Benjamin
Prugnolle, Franck
Anstey, Nicholas M.
Auburn, Sarah
Price, Ric N.
McCarthy, James S.
Kwiatkowski, Dominic P.
Newbold, Chris I.
Berriman, Matthew
Otto, Thomas D.
Title Plasmodium malariae and P. ovale genomes provide insights into malaria parasite evolution
Formatted title
Plasmodium malariae and P. ovale genomes provide insights into malaria parasite evolution
Journal name Nature   Check publisher's open access policy
ISSN 0028-0836
1476-4687
Publication date 2017-02-01
Sub-type Article (original research)
DOI 10.1038/nature21038
Open Access Status DOI
Volume 542
Issue 7639
Start page 101
End page 104
Total pages 4
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Collection year 2018
Language eng
Formatted abstract
Elucidation of the evolutionary history and interrelatedness of Plasmodium species that infect humans has been hampered by a lack of genetic information for three human-infective species: P. malariae and two P. ovale species (P. o. curtisi and P. o. wallikeri). These species are prevalent across most regions in which malaria is endemic and are often undetectable by light microscopy, rendering their study in human populations difficult. The exact evolutionary relationship of these species to the other human-infective species has been contested. Using a new reference genome for P. malariae and a manually curated draft P. o. curtisi genome, we are now able to accurately place these species within the Plasmodium phylogeny. Sequencing of a P. malariae relative that infects chimpanzees reveals similar signatures of selection in the P. malariae lineage to another Plasmodium lineage shown to be capable of colonization of both human and chimpanzee hosts. Molecular dating suggests that these host adaptations occurred over similar evolutionary timescales. In addition to the core genome that is conserved between species, differences in gene content can be linked to their specific biology. The genome suggests that P. malariae expresses a family of heterodimeric proteins on its surface that have structural similarities to a protein crucial for invasion of red blood cells. The data presented here provide insight into the evolution of the Plasmodium genus as a whole.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Medicine Publications
 
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