Dendritic cells in atherosclerosis: functions in immune regulation and beyond

Manthey, Helga D. and Zernecke, Alma (2011) Dendritic cells in atherosclerosis: functions in immune regulation and beyond. Thrombosis and Haemostasis, 106 5: 772-778. doi:10.1160/TH11-05-0296


Author Manthey, Helga D.
Zernecke, Alma
Title Dendritic cells in atherosclerosis: functions in immune regulation and beyond
Journal name Thrombosis and Haemostasis   Check publisher's open access policy
ISSN 0340-6245
Publication date 2011-11-01
Sub-type Article (original research)
DOI 10.1160/TH11-05-0296
Open Access Status Not yet assessed
Volume 106
Issue 5
Start page 772
End page 778
Total pages 7
Place of publication Stuttgart, Germany
Publisher Schattauer
Language eng
Abstract Chronic inflammation drives the development of atherosclerosis. Dendritic cells (DCs) are known as central mediators of adaptive immune responses and the development of immunological memory and tolerance. DCs are present in non-diseased arteries, and accumulate within atherosclerotic lesions where they can be localised in close vicinity to T cells. Recent work has revealed important functions of DCs in regulating immune mechanisms in atherogenesis, and vaccination strategies using DCs have been explored for treatment of disease. However, in line with a phenotypical and functional overlap with plaque macrophages vascular DCs were also identified to engulf lipids, thus contributing to lipid burden in the vessel wall and initiation of lesion growth. Furthermore, a function of DCs in regulating cholesterol homeostasis has been revealed. Finally, phenotypically distinct plasmacytoid dendritic cells (pDCs) have been identified within atherosclerotic lesions. This review will dissect the multifaceted contribution of DCs and pDCs to the initiation and progression of atherosclerosis and the experimental approaches utilising DCs in therapeutic vaccination strategies.
Keyword Atherosclerosis
Dendritic cells
Inflammation
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Australian Institute for Bioengineering and Nanotechnology Publications
 
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Created: Fri, 24 Mar 2017, 11:54:07 EST by Miss Helga Manthey on behalf of Learning and Research Services (UQ Library)