Alcohol consumption and the risk of colorectal cancer for mismatch repair gene mutation carriers

Ghazaleh Dashti, S., Buchanan, Daniel D., Jayasekara, Harindra, Ouakrim, Driss Ait, Clendenning, Mark, Rosty, Christophe, Winship, Ingrid M., MacRae, Finlay A., Giles, Graham G., Parry, Susan, Casey, Graham, Haile, Robert W., Gallinger, Steven, Le Marchand, Loic , Thibodeau, Stephen N., Lindor, Noralane M., Newcomb, Polly A., Potter, John D., Baron, John A., Hopper, John L., Jenkins, Mark A. and Win, Aung Ko (2017) Alcohol consumption and the risk of colorectal cancer for mismatch repair gene mutation carriers. Cancer Epidemiology, Biomarkers and Prevention, 26 3: 366-375. doi:10.1158/1055-9965.EPI-16-0496


Author Ghazaleh Dashti, S.
Buchanan, Daniel D.
Jayasekara, Harindra
Ouakrim, Driss Ait
Clendenning, Mark
Rosty, Christophe
Winship, Ingrid M.
MacRae, Finlay A.
Giles, Graham G.
Parry, Susan
Casey, Graham
Haile, Robert W.
Gallinger, Steven
Le Marchand, Loic
Thibodeau, Stephen N.
Lindor, Noralane M.
Newcomb, Polly A.
Potter, John D.
Baron, John A.
Hopper, John L.
Jenkins, Mark A.
Win, Aung Ko
Title Alcohol consumption and the risk of colorectal cancer for mismatch repair gene mutation carriers
Journal name Cancer Epidemiology, Biomarkers and Prevention   Check publisher's open access policy
ISSN 1055-9965
1538-7755
Publication date 2017-03-01
Sub-type Article (original research)
DOI 10.1158/1055-9965.EPI-16-0496
Open Access Status Not yet assessed
Volume 26
Issue 3
Start page 366
End page 375
Total pages 10
Place of publication Philadelphia, PA, United States
Publisher American Association for Cancer Research
Collection year 2018
Language eng
Formatted abstract
Background: People with germline mutation in one of the DNA mismatch repair (MMR) genes have increased colorectal cancer risk. For these high-risk people, study findings of the relationship between alcohol consumption and colorectal cancer risk have been inconclusive.

Methods: 1,925 MMR gene mutations carriers recruited into the Colon Cancer Family Registry who had completed a questionnaire on lifestyle factors were included. Weighted Cox proportional hazard regression models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for the association between alcohol consumption and colorectal cancer.

Results: Colorectal cancer was diagnosed in 769 carriers (40%) at a mean (SD) age of 42.6 (10.3) years. Compared with abstention, ethanol consumption from any alcoholic beverage up to 14 g/day and >28 g/day was associated with increased colorectal cancer risk (HR, 1.50; 95% CI, 1.09-2.07 and 1.69; 95% CI, 1.07-2.65, respectively; Ptrend = 0.05), and colon cancer risk (HR, 1.78; 95% CI, 1.27-2.49 and 1.94; 95% CI, 1.19-3.18, respectively; Ptrend = 0.02). However, there was no clear evidence for an association with rectal cancer risk. Also, there was no evidence for associations between consumption of individual alcoholic beverage types (beer, wine, spirits) and colorectal, colon, or rectal cancer risk.

Conclusions: Our data suggest that alcohol consumption, particularly more than 28 g/day of ethanol (∼2 standard drinks of alcohol in the United States), is associated with increased colorectal cancer risk for MMR gene mutation carriers. Impact: Although these data suggested that alcohol consumption in MMR carriers was associated with increased colorectal cancer risk, there was no evidence of a dose-response, and not all types of alcohol consumption were associated with increased risk.

Impact: Although these data suggested that alcohol consumption in MMR carriers was associated with increased colorectal cancer risk, there was no evidence of a dose-response, and not all types of alcohol consumption were associated with increased risk.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Medicine Publications
 
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