Dendritic cells in human lung disease: recent advances

Upham, John W. and Xi, Yang (2017) Dendritic cells in human lung disease: recent advances. Chest, 151 3: 668-673. doi:10.1016/j.chest.2016.09.030

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Author Upham, John W.
Xi, Yang
Title Dendritic cells in human lung disease: recent advances
Journal name Chest   Check publisher's open access policy
ISSN 1931-3543
Publication date 2017-03-01
Year available 2016
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.chest.2016.09.030
Open Access Status File (Author Post-print)
Volume 151
Issue 3
Start page 668
End page 673
Total pages 6
Place of publication Glenview, IL, United States
Publisher American College of Chest Physicians
Language eng
Subject 2740 Pulmonary and Respiratory Medicine
2706 Critical Care and Intensive Care Medicine
2705 Cardiology and Cardiovascular Medicine
Abstract Dendritic cells (DCs) are potent antigen-presenting cells. Because of their particular ability to initiate and regulate cell mediated and humoral immune responses, there is considerable interest in the role that DCs play in the pathogenesis of various lung diseases, especially those in which there is an excessive immune response to specific antigens (as in asthma) or a deficient immune response (as in lung cancer). A number of DC subpopulations have been defined in the lungs, including myeloid or conventional DCs that initiate T-cell immunity and antibody production and plasmacytoid DCs that have an important role in antiviral immunity and immune tolerance. Although an extensive body of literature has documented the role that DCs play in experimental models of lung disease, this review will highlight recent advances in our understanding of DC function in human disease, including asthma, COPD, antimicrobial immunity, and lung cancer. The future is likely to see new approaches whereby antigens and small molecules are targeted to receptors on particular DC subpopulations in order to modify pulmonary immune responses.
Keyword Dendritic cells
Immune regulation
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
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