Managing the oral side effects of medications used to treat multiple sclerosis

Cockburn, N., Pateman, K., Taing, M. W., Pradhan, A. and Ford, P. J. (2017) Managing the oral side effects of medications used to treat multiple sclerosis. Australian Dental Journal, 62 3: 331-336. doi:10.1111/adj.12510

Author Cockburn, N.
Pateman, K.
Taing, M. W.
Pradhan, A.
Ford, P. J.
Title Managing the oral side effects of medications used to treat multiple sclerosis
Journal name Australian Dental Journal   Check publisher's open access policy
ISSN 0045-0421
Publication date 2017-03-09
Year available 2017
Sub-type Article (original research)
DOI 10.1111/adj.12510
Open Access Status Not yet assessed
Volume 62
Issue 3
Start page 331
End page 336
Total pages 13
Place of publication Chichester, West Sussex, United Kingdom
Publisher Wiley-Blackwell Publishing
Language eng
Subject 3500 Dentistry
Abstract Background Many medications used to manage multiple sclerosis (MS) affect oral health. This review aimed to identify the oral side effects of the current drugs recommended in Australia to treat MS and make dental practitioners aware of the range of symptoms. Methods The Australian Therapeutic Guidelines and the Australian Medicines Handbook were searched for medications used to treat MS. For each medication, the generic name, class, route of administration, dosage and drug company reported side-effects were extracted from the online Monthly Index of Medical Specialties (MIMs) database. Meyler's Side Effect of Drugs Encyclopaedia was used to identify any additional oral adverse reactions to medications used to treat MS. Results Fourteen drugs were identified for the treatment of MS progression and 13 drugs for the treatment of MS symptoms. For these medications, 18 oral side effects were documented: xerostomia was the most common, followed by dysgeusia, dysphagia, mouth ulceration and sinusitis. Anticholinergic drugs caused xerostomia while immunosuppressants resulted in more infection related side-effects. Conclusions Dental practitioners should be aware of the range of symptoms likely to be reported by this population. Clinicians are encouraged to continue providing dental care for their patients who develop MS and refer complex cases to specialists.
Keyword Chronic Orofacial Pain
Atypical Odontalgia
Gingival Overgrowth
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ
Additional Notes Published online 9 March 2017. Accepted manuscript

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Dentistry Publications
School of Pharmacy Publications
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Created: Mon, 20 Mar 2017, 12:26:56 EST by Mr Meng-wong Taing on behalf of School of Pharmacy