Nonnucleoside reverse transcriptase inhibitor fold change or plasma concentration as a predictor of virological response over 48 weeks in highly treatment experienced hiv-positive individuals

Winston, Alan, Amin, Janaki , Hales, Gill, Cooper, David A. and Emery, Sean (2006) Nonnucleoside reverse transcriptase inhibitor fold change or plasma concentration as a predictor of virological response over 48 weeks in highly treatment experienced hiv-positive individuals. Aids Research and Human Retroviruses, 22 4: 338-341. doi:10.1089/aid.2006.22.338


Author Winston, Alan
Amin, Janaki
Hales, Gill
Cooper, David A.
Emery, Sean
Title Nonnucleoside reverse transcriptase inhibitor fold change or plasma concentration as a predictor of virological response over 48 weeks in highly treatment experienced hiv-positive individuals
Journal name Aids Research and Human Retroviruses   Check publisher's open access policy
ISSN 0889-2229
1931-8405
Publication date 2006-04-19
Year available 2006
Sub-type Article (original research)
DOI 10.1089/aid.2006.22.338
Open Access Status Not yet assessed
Volume 22
Issue 4
Start page 338
End page 341
Total pages 4
Place of publication New Rochelle, United States
Publisher Mary Ann Liebert
Language eng
Formatted abstract
The nonnucleoside reverse transcriptase inhibitors (NNRTI) have low genetic barriers to resistance. Resistance can sometimes be overcome by increasing drug exposure. We assessed factors associated with 48-week virological response in treatment-experienced individuals receiving NNRTI therapy including resistance testing results and plasma drug exposure. Of 62 individuals assigned a new NNRTI-based regimen following resistance testing therapy consisted of efavirenz in 35 (56%) and nevirapine in 27 (44%) individuals. NNRTI fold change (FC) was determined from resistance test at baseline and plasma drug concentration at week 4. Mean time weighted change from baseline VL was –0.68 log over 48 weeks. Significant associations with change from baseline VL included baseline VL and FC whereas plasma drug concentration was not associated. In this cohort of highly treatment-experienced individuals treated with NNRTI regimens, we did not observe a significant association between NNRTI plasma concentration and virological response.
Keyword Immunology
Infectious Diseases
Virology
Immunology
Infectious Diseases
Virology
IMMUNOLOGY
INFECTIOUS DISEASES
VIROLOGY
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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