DNA methylation mediates neural processing after odor learning in the honeybee

Biergans, Stephanie D., Claudianos, Charles, Reinhard, Judith and Galizia, C. Giovanni (2017) DNA methylation mediates neural processing after odor learning in the honeybee. Scientific Reports, 7 43635.1-43635.11. doi:10.1038/srep43635

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Author Biergans, Stephanie D.
Claudianos, Charles
Reinhard, Judith
Galizia, C. Giovanni
Title DNA methylation mediates neural processing after odor learning in the honeybee
Journal name Scientific Reports   Check publisher's open access policy
ISSN 2045-2322
Publication date 2017-02-27
Year available 2017
Sub-type Article (original research)
DOI 10.1038/srep43635
Open Access Status DOI
Volume 7
Start page 43635.1
End page 43635.11
Total pages 11
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Formatted abstract
DNA methyltransferases (Dnmts) - epigenetic writers catalyzing the transfer of methyl-groups to cytosine (DNA methylation) – regulate different aspects of memory formation in many animal species. In honeybees, Dnmt activity is required to adjust the specificity of olfactory reward memories and bees’ relearning capability. The physiological relevance of Dnmt-mediated DNA methylation in neural networks, however, remains unknown. Here, we investigated how Dnmt activity impacts neuroplasticity in the bees’ primary olfactory center, the antennal lobe (AL) an equivalent of the vertebrate olfactory bulb. The AL is crucial for odor discrimination, an indispensable process in forming specific odor memories. Using pharmacological inhibition, we demonstrate that Dnmt activity influences neural network properties during memory formation in vivo. We show that Dnmt activity promotes fast odor pattern separation in trained bees. Furthermore, Dnmt activity during memory formation increases both the number of responding glomeruli and the response magnitude to a novel odor. These data suggest that Dnmt activity is necessary for a form of homoeostatic network control which might involve inhibitory interneurons in the AL network.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Queensland Brain Institute Publications
 
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Created: Wed, 15 Mar 2017, 11:43:38 EST by Emma Schleiger on behalf of Queensland Brain Institute