Neuronal genome plasticity: retrotransposons, environment and disease

Kempen, Marie-Jeanne H. C., Bodea, Gabriela O. and Faulkner, Geoffrey J. (2017). Neuronal genome plasticity: retrotransposons, environment and disease. In Gael Cristofari (Ed.), Human retrotransposons in health and disease (pp. 107-125) New York, NY, United States: Springer. doi:10.1007/978-3-319-48344-3_5


Author Kempen, Marie-Jeanne H. C.
Bodea, Gabriela O.
Faulkner, Geoffrey J.
Title of chapter Neuronal genome plasticity: retrotransposons, environment and disease
Title of book Human retrotransposons in health and disease
Place of Publication New York, NY, United States
Publisher Springer
Publication Year 2017
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1007/978-3-319-48344-3_5
Open Access Status Not yet assessed
ISBN 9783319483436
9783319483443
Editor Gael Cristofari
Chapter number 5
Start page 107
End page 125
Total pages 19
Total chapters 13
Language eng
Abstract/Summary The neuronal genome has long been considered as a stably persisting entity interpreted as the foundation of neurobiology. Over the past decade, it has become increasingly clear that mobile genetic elements, such as the retrotransposon LINE-1 (L1), are actively transcribed and transpose in the healthy brain. L1 activity therefore provides a route to somatic genome diversity and dynamism in neuronal populations. Here, we discuss the discovery of L1 retrotransposition during neurogenesis, and consider how neuronal cells regulate retrotransposition in response to endogenous and environmental stimuli. We also bring forward hypotheses relating to how L1 impacts normal brain development and function, as well as how abnormal L1 mobilisation could contribute to neurological disease susceptibility and pathophysiology.
Keyword Retrotransposon
LINE-1
Neuron
Neurogenesis
Mosaicism
Q-Index Code B1
Q-Index Status Provisional Code
Institutional Status UQ

 
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Created: Tue, 14 Mar 2017, 14:20:54 EST by Gabriela-oana Bodea on behalf of Queensland Brain Institute