Polygenic risk for five psychiatric disorders and cross-disorder and disorder-specific neural connectivity in two independent populations

Wang, Tianqi, Zhang, Xiaolong, Li, Ang, Zhu, Meifang, Liu, Shu, Qin, Wen, Li, Jin, Yu, Chunshui , Jiang, Tianzi and Liu, Bing (2017) Polygenic risk for five psychiatric disorders and cross-disorder and disorder-specific neural connectivity in two independent populations. NeuroImage: Clinical, 14 8: 441-449. doi:10.1016/j.nicl.2017.02.011


Author Wang, Tianqi
Zhang, Xiaolong
Li, Ang
Zhu, Meifang
Liu, Shu
Qin, Wen
Li, Jin
Yu, Chunshui
Jiang, Tianzi
Liu, Bing
Title Polygenic risk for five psychiatric disorders and cross-disorder and disorder-specific neural connectivity in two independent populations
Journal name NeuroImage: Clinical   Check publisher's open access policy
ISSN 2213-1582
Publication date 2017-03-01
Year available 1998
Sub-type Article (original research)
DOI 10.1016/j.nicl.2017.02.011
Open Access Status DOI
Volume 14
Issue 8
Start page 441
End page 449
Total pages 9
Place of publication Amsterdam, Netherlands
Publisher Elsevier BV
Language eng
Subject 2741 Radiology Nuclear Medicine and imaging
2808 Neurology
2728 Clinical Neurology
2805 Cognitive Neuroscience
Abstract Major psychiatric disorders, including attention deficit hyperactivity disorder (ADHD), autism (AUT), bipolar disorder (BD), major depressive disorder (MDD), and schizophrenia (SZ), are highly heritable and polygenic. Evidence suggests that these five disorders have both shared and distinct genetic risks and neural connectivity abnormalities. To measure aggregate genetic risks, the polygenic risk score (PGRS) was computed. Two independent general populations (N = 360 and N = 323) were separately examined to investigate whether the cross-disorder PGRS and PGRS for a specific disorder were associated with individual variability in functional connectivity. Consistent altered functional connectivity was found with the bilateral insula: for the left supplementary motor area and the left superior temporal gyrus with the cross-disorder PGRS, for the left insula and right middle and superior temporal lobe associated with the PGRS for autism, for the bilateral midbrain, posterior cingulate, cuneus, and precuneus associated with the PGRS for BD, and for the left angular gyrus and the left dorsolateral prefrontal cortex associated with the PGRS for schizophrenia. No significant functional connectivity was found associated with the PGRS for ADHD and MDD. Our findings indicated that genetic effects on the cross-disorder and disorder-specific neural connectivity of common genetic risk loci are detectable in the general population. Our findings also indicated that polygenic risk contributes to the main neurobiological phenotypes of psychiatric disorders and that identifying cross-disorder and specific functional connectivity related to polygenic risks may elucidate the neural pathways for these disorders.
Keyword Cross-disorder
Disorder-specific
FMRI
Neural connectivity
Polygenic risk score
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 91132301

2016YFC0904301
XDB02030300
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Queensland Brain Institute Publications
 
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