The challenge of bias-free coil combination for quantitative susceptibility mapping at ultra-high field

Bollmann, Steffen, Robinson, Simon Daniel, O'Brien, Kieran, Vegh, Viktor, Janke, Andrew, Marstaller, Lars, Reutens, David and Barth, Markus (2017) The challenge of bias-free coil combination for quantitative susceptibility mapping at ultra-high field. Magnetic Resonance in Medicine, . doi:10.1002/mrm.26644

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads

Author Bollmann, Steffen
Robinson, Simon Daniel
O'Brien, Kieran
Vegh, Viktor
Janke, Andrew
Marstaller, Lars
Reutens, David
Barth, Markus
Title The challenge of bias-free coil combination for quantitative susceptibility mapping at ultra-high field
Journal name Magnetic Resonance in Medicine   Check publisher's open access policy
ISSN 1522-2594
0740-3194
Publication date 2017-03-01
Sub-type Article (original research)
DOI 10.1002/mrm.26644
Open Access Status File (Author Post-print)
Total pages 11
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Language eng
Abstract Quantitative susceptibility mapping is a technique to estimate the magnetic property of tissue with particularly high sensitivity at ultra-high field. However, a key challenge at ultra-high field is the combination of phase data acquired using phased array receive coils. Several methods for combining phase data have been proposed, but the influence of coil combination choices on susceptibility quantitation has not been studied systematically.

We combined phase data using COMPOSER (COMbining Phase data using a Short Echo-time Reference scan) and a reference-free channel-by-channel method. We investigated the effect of the chosen combination method on susceptibility results in a group of 28 participants at 7 Tesla.

Our results show that reference scans can bias susceptibility values. Although the proposed reference-free channel-by-channel method cannot remove transmit field phase, it shows comparable results to the COMPOSER method in which a high-resolution ultrashort echo-time reference scan was used.

We conclude that ultrashort echo-time reference scans reduce quantitation bias and remove the transmit field phase when using COMPOSER to combine phase data, and not combining the phase data before susceptibility processing avoids this bias, resulting in comparable results. Magn Reson Med, 2017. © 2017 InternationalSociety for Magnetic Resonance in Medicine.
Formatted abstract
Purpose: Quantitative susceptibility mapping is a technique to estimate the magnetic property of tissue with particularly high sensitivity at ultra-high field. However, a key challenge at ultra-high field is the combination of phase data acquired using phased array receive coils. Several methods for combining phase data have been proposed, but the influence of coil combination choices on susceptibility quantitation has not been studied systematically.

Methods: We combined phase data using COMPOSER (COMbining Phase data using a Short Echo-time Reference scan) and a reference-free channel-by-channel method. We investigated the effect of the chosen combination method on susceptibility results in a group of 28 participants at 7 Tesla.

Results: Our results show that reference scans can bias susceptibility values. Although the proposed reference-free channel-by-channel method cannot remove transmit field phase, it shows comparable results to the COMPOSER method in which a high-resolution ultrashort echo-time reference scan was used.

Conclusions: We conclude that ultrashort echo-time reference scans reduce quantitation bias and remove the transmit field phase when using COMPOSER to combine phase data, and not combining the phase data before susceptibility processing avoids this bias, resulting in comparable results.
Keyword 3D EPI
Atlas-based segmentation
COMPOSER
PETRA
QSM
Ultra-high field
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Centre for Advanced Imaging Publications
 
Versions
Version Filter Type
Citation counts: Scopus Citation Count Cited 0 times in Scopus Article
Google Scholar Search Google Scholar
Created: Tue, 14 Mar 2017, 00:24:17 EST by System User on behalf of Learning and Research Services (UQ Library)