Prevention of DNA damage in human skin by topical sunscreens

Olsen, Catherine M. , Wilson, Louise F. , Green, Adele C. , Biswas, Neela, Loyalka, Juhi and Whiteman, David C. (2017) Prevention of DNA damage in human skin by topical sunscreens. Photodermatology, Photoimmunology & Photomedicine, 33 3: 135-142. doi:10.1111/phpp.12298

Author Olsen, Catherine M.
Wilson, Louise F.
Green, Adele C.
Biswas, Neela
Loyalka, Juhi
Whiteman, David C.
Title Prevention of DNA damage in human skin by topical sunscreens
Journal name Photodermatology, Photoimmunology & Photomedicine   Check publisher's open access policy
ISSN 1600-0781
Publication date 2017-02-01
Sub-type Article (original research)
DOI 10.1111/phpp.12298
Open Access Status Not yet assessed
Volume 33
Issue 3
Start page 135
End page 142
Total pages 8
Place of publication Hoboken, NJ, United States
Publisher Wiley-Blackwell Publishing
Language eng
Formatted abstract
Background/purpose: There is strong evidence that topical sunscreens, designed to protect against ultraviolet radiation (UVR)-induced erythema, decrease the amount of UVR to which the skin is exposed, but their effectiveness in reducing UVR-induced DNA damage in vivo has not been well quantified.

Methods: We systematically reviewed the published literature (1990-2015) to determine whether sunscreens prevent DNA damage in human skin when applied prior to UVR exposure. We included experimental studies measuring UVR-induced DNA damage in human skin in vivo with and without sunscreens and excluded studies conducted in animal models and cell lines. Eligible studies were identified by computerized search of bibliographic databases, supplemented by hand-searching the reference lists of retrieved articles.

Results: We identified ten eligible studies. Despite heterogeneity in methodological approaches, including the sun protection factors of the sunscreens assessed, range of skin types examined, the UVR exposure time and dose, the timing of post-irradiation biopsies and in the markers of DNA damage examined, all studies reported markedly reduced (or nil) UVR-induced DNA damage on sunscreen-protected skin.

Conclusion: Our review of the experimental evidence supports a protective effect of topical sunscreens in preventing UVR-induced DNA damage in human skin cells in vivo.
Keyword DNA damage
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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