The type and incidence of adverse drug events in ageing medical inpatients and their effect on length of hospital stay

Paradissis, Chariclia, Coombes, Ian D. , Donovan, Peter, Doran, Elizabeth, Mckean, Mitchell and Barras, Michael A. (2017) The type and incidence of adverse drug events in ageing medical inpatients and their effect on length of hospital stay. Journal of Pharmacy Practice and Research, . doi:10.1002/jppr.1255


Author Paradissis, Chariclia
Coombes, Ian D.
Donovan, Peter
Doran, Elizabeth
Mckean, Mitchell
Barras, Michael A.
Title The type and incidence of adverse drug events in ageing medical inpatients and their effect on length of hospital stay
Journal name Journal of Pharmacy Practice and Research   Check publisher's open access policy
ISSN 1445-937X
2055-2335
Publication date 2017-02-24
Sub-type Article (original research)
DOI 10.1002/jppr.1255
Open Access Status Not yet assessed
Total pages 8
Place of publication Chichester, West Sussex, United Kingdom
Publisher Wiley-Blackwell Publishing
Language eng
Formatted abstract
Aims: To determine the proportion of older medical patients who have an adverse drug event (ADE) during admission to hospital and assess the association with hospital length of stay (LOS).

Methods: A retrospective evaluation of eligible patients, aged greater than 65 years, consecutively admitted to a medical ward at the Royal Brisbane and Women's Hospital, Australia. Patient medication charts, medical notes and laboratory results were reviewed using an ADE trigger tool to identify potential ADEs during admission. A clinical panel examined and confirmed any true ADEs and the corresponding causative agents. LOS was compared between patients who did and did not have an ADE.

Results: A total of 164 patients were recruited over 30 days. The trigger tool identified a total of 69 triggers from 40 patients (24.3%) with a potential ADE during admission, of which 12 patients (7.3%) had a true ADE. The main drug categories implicated included cardiovascular, anti-infective and haematological agents. The group of patients with an ADE had a longer median (25th, 75th percentile) LOS when compared to patients without an ADE: 6.5 (3.75, 11) versus 4 (2, 7) days (p = 0.043).

Conclusion: Approximately 7% of older in-patients experience an ADE, which has a significant association with an increase in their LOS. To minimise patient harm, undesirable high-risk drugs should be avoided and vigilant monitoring must occur if they need to be prescribed. An adequately powered, multi-site study is required and preventative strategies should be further explored.
Keyword Drug safety
Patient safety
Prescribing
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Medicine Publications
School of Pharmacy Publications
 
Versions
Version Filter Type
Citation counts: Scopus Citation Count Cited 0 times in Scopus Article
Google Scholar Search Google Scholar
Created: Tue, 14 Mar 2017, 00:24:17 EST by System User on behalf of Learning and Research Services (UQ Library)