The cardiovascular and neurotoxic effects of the venoms of six bony and cartilaginous fish species

Han, Han, Baumann, Kate, Casewell, Nicholas R., Ali, Syed A., Dobson, James, Koludarov, Ivan, Debono, Jordan, Cutmore, Scott C., Rajapakse, Niwanthi W., Jackson, Timothy N. W., Jones, Rob, Hodgson, Wayne C., Fry, Bryan G. and Kuruppu, Sanjaya (2017) The cardiovascular and neurotoxic effects of the venoms of six bony and cartilaginous fish species. Toxins, 9 2: . doi:10.3390/toxins9020067


Author Han, Han
Baumann, Kate
Casewell, Nicholas R.
Ali, Syed A.
Dobson, James
Koludarov, Ivan
Debono, Jordan
Cutmore, Scott C.
Rajapakse, Niwanthi W.
Jackson, Timothy N. W.
Jones, Rob
Hodgson, Wayne C.
Fry, Bryan G.
Kuruppu, Sanjaya
Title The cardiovascular and neurotoxic effects of the venoms of six bony and cartilaginous fish species
Journal name Toxins   Check publisher's open access policy
ISSN 2072-6651
Publication date 2017-02-01
Sub-type Article (original research)
DOI 10.3390/toxins9020067
Open Access Status DOI
Volume 9
Issue 2
Total pages 10
Place of publication Basel, Switzerland
Publisher M D P I AG
Collection year 2018
Language eng
Formatted abstract
Fish venoms are often poorly studied, in part due to the difficulty in obtaining, extracting, and storing them. In this study, we characterize the cardiovascular and neurotoxic effects of the venoms from the following six species of fish: the cartilaginous stingrays Neotrygon kuhlii and Himantura toshi, and the bony fish Platycephalus fucus, Girella tricuspidata, Mugil cephalus, and Dentex tumifrons. All venoms (10–100 μg/kg, i.v.), except G. tricuspidata and P. fuscus, induced a biphasic response on mean arterial pressure (MAP) in the anesthetised rat. P. fucus venom exhibited a hypotensive response, while venom from G. tricuspidata displayed a single depressor response. All venoms induced cardiovascular collapse at 200 μg/kg, i.v. The in vitro neurotoxic effects of venom were examined using the chick biventer cervicis nerve-muscle (CBCNM) preparation. N. kuhlii, H. toshi, and P. fucus venoms caused concentration-dependent inhibition of indirect twitches in the CBCNM preparation. These three venoms also inhibited responses to exogenous acetylcholine (ACh) and carbachol (CCh), but not potassium chloride (KCl), indicating a post-synaptic mode of action. Venom from G. tricuspidata, M. cephalus, and D. tumifrons had no significant effect on indirect twitches or agonist responses in the CBCNM. Our results demonstrate that envenoming by these species of fish may result in moderate cardiovascular and/or neurotoxic effects. Future studies aimed at identifying the molecules responsible for these effects could uncover potentially novel lead compounds for future pharmaceuticals, in addition to generating new knowledge about the evolutionary relationships between venomous animals.
Keyword Cardiovascular
Fish
Neuromuscular
Toxin
Venom
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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School of Biological Sciences Publications
 
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