Cyclotides as drug design scaffolds

Craik, David J. and Du, Junqiao (2017) Cyclotides as drug design scaffolds. Current Opinion in Chemical Biology, 38 8-16. doi:10.1016/j.cbpa.2017.01.018

Author Craik, David J.
Du, Junqiao
Title Cyclotides as drug design scaffolds
Journal name Current Opinion in Chemical Biology   Check publisher's open access policy
ISSN 1879-0402
Publication date 2017-06-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.cbpa.2017.01.018
Open Access Status Not yet assessed
Volume 38
Start page 8
End page 16
Total pages 9
Place of publication Kidlington, Oxford, United Kingdom
Publisher Elsevier
Collection year 2018
Language eng
Abstract Cyclotides are ultra-stable peptides derived from plants. They are around 30 amino acids in size and are characterized by their head-to-tail cyclic backbone and cystine knot. Their exceptional stability and tolerance to sequence substitutions has led to their use as frameworks in drug design. This article describes recent developments in this field, particularly developments over the last two years relating to the grafting of bioactive peptide sequences into the cyclic cystine knot framework of cyclotides to stabilize the sequences. Grafted cyclotides have now been developed that interact with protein or enzyme targets, both extracellular and intracellular, as well as with cell surface receptors and membranes.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
Institute for Molecular Bioscience - Publications
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