Investigation of p16 status, chemotherapy regimen and other nutrition markers for predicting gastrostomy in patients with head and neck cancer

Brown, Teresa E., Wittholz, Kym, Way, Mandy, Banks, Merrilyn D., Hughes, Brett G. M., Lin, Charles Y., Kenny, Lizbeth M. and Bauer, Judith D. (2017) Investigation of p16 status, chemotherapy regimen and other nutrition markers for predicting gastrostomy in patients with head and neck cancer. Head and Neck, 39 5: 868-875. doi:10.1002/hed.24630


Author Brown, Teresa E.
Wittholz, Kym
Way, Mandy
Banks, Merrilyn D.
Hughes, Brett G. M.
Lin, Charles Y.
Kenny, Lizbeth M.
Bauer, Judith D.
Title Investigation of p16 status, chemotherapy regimen and other nutrition markers for predicting gastrostomy in patients with head and neck cancer
Journal name Head and Neck   Check publisher's open access policy
ISSN 1097-0347
1043-3074
Publication date 2017-02-23
Sub-type Article (original research)
DOI 10.1002/hed.24630
Open Access Status Not yet assessed
Volume 39
Issue 5
Start page 868
End page 875
Total pages 8
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Collection year 2018
Language eng
Formatted abstract
Background: The purpose of this study was to determine if p16 status, chemotherapy regimen, or other nutrition markers could improve protocol accuracy in predicting proactive gastrostomy in patients with head and neck cancer.

Methods: Patients who received curative treatment from July 2010 to June 2011 were included (n = 269). Associations among dependent variables (age, sex, tumor site, staging, treatment, p16 status, albumin, and Malnutrition Screening Tool [MST] score), the protocol risk rating, and requirement for proactive gastrostomy were examined.

Results: Current protocol correctly identified 81 of 88 high-risk patients (92%) for gastrostomy, but incorrectly classified 32 of 181 low-risk patients (18%). Analysis of low-risk patients with oral or oropharyngeal cancers, found p16-positive disease had 4.4 times greater odds (p = .049), and those at risk of malnutrition had 4.5 times greater odds (p = .019) of requiring gastrostomy.

Conclusion: Malnutrition risk and p16 status could be used to identify further patients who may benefit from proactive gastrostomy.
Keyword Chemotherapy
Human papillomavirus (HPV)
Head and neck cancer
Gastrostomy
Malnutrition
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Human Movement and Nutrition Sciences Publications
School of Medicine Publications
 
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Created: Fri, 10 Mar 2017, 09:13:45 EST by Sandrine Ducrot on behalf of School of Human Movement and Nutrition Sciences