The application of self-assembled nanostructures in peptide-based subunit vaccine development

Zhao, Guangzu, Chandrudu, Saranya, Skwarczynski, Mariusz and Toth, Istvan (2017) The application of self-assembled nanostructures in peptide-based subunit vaccine development. European Polymer Journal, 93 670-681. doi:10.1016/j.eurpolymj.2017.02.014


Author Zhao, Guangzu
Chandrudu, Saranya
Skwarczynski, Mariusz
Toth, Istvan
Title The application of self-assembled nanostructures in peptide-based subunit vaccine development
Journal name European Polymer Journal   Check publisher's open access policy
ISSN 0014-3057
1873-1945
Publication date 2017-02-10
Sub-type Article (original research)
DOI 10.1016/j.eurpolymj.2017.02.014
Open Access Status Not yet assessed
Volume 93
Start page 670
End page 681
Total pages 12
Place of publication Kidlington, Oxford, United Kingdom
Publisher Pergamon Press
Language eng
Subject 3100 Physics and Astronomy
2507 Polymers and Plastics
1605 Organic Chemistry
Abstract Peptide based-vaccines are becoming one of the most widely investigated prophylactic and therapeutic health care interventions against a variety of diseases, including cancer. However, the lack of a safe and highly efficient adjuvant (immune stimulant) is regarded as the biggest obstacle to vaccine development. The incorporation of a peptide antigen in a nanostructure-based delivery system was recently shown to overcome this obstacle. Nanostructures are often formed from antigens conjugated to molecules such as polymers, lipids, and peptide, with the help of self-assembly phenomenon. This review describes the application of self-assembly process for the production of peptide-based vaccine candidates and the ability of these nanostructures to stimulate humoral and cellular immune responses.
Keyword Conjugation
Lipopeptide
Nanofiber
Nanoparticle
Polymer
Self-assembly
Vaccine
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 496600
Institutional Status UQ

 
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