Obesity, weight change, and chronic kidney disease in patients with type 2 diabetes mellitus: a longitudinal study in Taiwan

Chung, Hsin-Fang, Al Mamun, Abdullah, Huang, Meng-Chuan, Long, Kurt Z., Huang, Ya-Fang, Shin, Shyi-Jang, Hwang, Shang-Jyh and Hsu, Chih-Cheng (2017) Obesity, weight change, and chronic kidney disease in patients with type 2 diabetes mellitus: a longitudinal study in Taiwan. Journal of Diabetes, . doi:10.1111/1753-0407.12514


Author Chung, Hsin-Fang
Al Mamun, Abdullah
Huang, Meng-Chuan
Long, Kurt Z.
Huang, Ya-Fang
Shin, Shyi-Jang
Hwang, Shang-Jyh
Hsu, Chih-Cheng
Title Obesity, weight change, and chronic kidney disease in patients with type 2 diabetes mellitus: a longitudinal study in Taiwan
Journal name Journal of Diabetes   Check publisher's open access policy
ISSN 1753-0407
1753-0393
Publication date 2017-02-05
Sub-type Article (original research)
DOI 10.1111/1753-0407.12514
Open Access Status Not yet assessed
Total pages 11
Place of publication Weinheim, Germany
Publisher Wiley - VCH
Collection year 2018
Language eng
Formatted abstract
Background: The aim of the present study was to investigate relationships between the risk of chronic kidney disease (CKD) and obesity and weight changes in Asian patients with type 2 diabetes.

Methods: At baseline (2003-05), 1187 diabetic patients aged 30-70 years were recruited to the study, with follow-up surveys completed in 2008, 2009, and 2010. Chronic kidney disease was defined as an estimated glomerular filtration rate (eGFR) <60 mL/min per 1.73 m2; body mass index (BMI) was categorised as normal (18.5-22.9 kg/m2), overweight (23-27.4 kg/m2), or obese (≥27.5 kg/m2); waist circumference (WC) ≥80 cm for women and ≥90 cm for men was taken to indicate abdominal obesity. Changes in weight and WC were calculated from baseline to each follow-up survey. Relative risk (RR) and 95% confidence intervals (CIs) of CKD were estimated. To estimate the risk for incident CKD, associations were examined in patients without CKD at baseline (n = 881).

Results: Over 7 years of follow-up, obesity (RR 1.48; 95% CI 1.08-2.04; P = 0.015) and high WC (RR 1.23; 95% CI 1.00-1.52; P = 0.049) were associated with CKD after adjusting for covariates. Among participants without CKD at baseline, those who gained >10% weight (RR 1.43; 95% CI 1.07-1.90; P = 0.015) and in whom WC increased >15% (RR 1.37; 95% CI 1.01-1.85; P = 0.045) had a higher risk of incident CKD than those who remained stable (±5% changes in weight or WC).

Conclusions: Diabetic patients who are obese and those with excessive central fat were more likely to have CKD. Large weight gain (>10%) and increases in WC (>15%) independently predicted incident CKD.
Keyword Asian
Chronic kidney disease
Obesity
Type 2 diabetes
Weight change
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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