Nuclear factor one transcription factors as epigenetic regulators in cancer

Fane, Mitchell, Harris, Lachlan, Smith, Aaron G. and Piper, Michael (2017) Nuclear factor one transcription factors as epigenetic regulators in cancer. International Journal of Cancer, 140 12: 2634-2641. doi:10.1002/ijc.30603

Author Fane, Mitchell
Harris, Lachlan
Smith, Aaron G.
Piper, Michael
Title Nuclear factor one transcription factors as epigenetic regulators in cancer
Journal name International Journal of Cancer   Check publisher's open access policy
ISSN 1097-0215
Publication date 2017-02-08
Year available 2017
Sub-type Article (original research)
DOI 10.1002/ijc.30603
Open Access Status Not yet assessed
Volume 140
Issue 12
Start page 2634
End page 2641
Total pages 8
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Language eng
Subject 2700 Medicine
2730 Oncology
1306 Cancer Research
Abstract Tumour heterogeneity poses a distinct obstacle to therapeutic intervention. While the initiation of tumours across various physiological systems is frequently associated with signature mutations in genes that drive proliferation and bypass senescence, increasing evidence suggests that tumour progression and clonal diversity is driven at an epigenetic level. The tumour microenvironment plays a key role in driving diversity as cells adapt to demands imposed during tumour growth, and is thought to drive certain subpopulations back to a stem cell-like state. This stem cell-like phenotype primes tumour cells to react to external cues via the use of developmental pathways that facilitate changes in proliferation, migration and invasion. Because the dynamism of this stem cell-like state requires constant chromatin remodelling and rapid alterations at regulatory elements, it is of great therapeutic interest to identify the cell-intrinsic factors that confer these epigenetic changes that drive tumour progression. The nuclear factor one (NFI) family are transcription factors that play an important role in the development of many mammalian organ systems. While all four family members have been shown to act as either oncogenes or tumour suppressors across various cancer models, evidence has emerged implicating them as key epigenetic regulators during development and within tumours. Notably, NFIs have also been shown to regulate chromatin accessibility at distal regulatory elements that drive tumour cell dissemination and metastasis. Here we summarize the role of the NFIs in cancer, focusing largely on the potential mechanisms associated with chromatin remodelling and epigenetic modulation of gene expression.
Keyword Oncology
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 1057751
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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