Therapeutic approaches targeting MYC-Driven prostate cancer

Rebello, Richard J., Pearson, Richard B., Hannan, Ross D. and Furic, Luc (2017) Therapeutic approaches targeting MYC-Driven prostate cancer. Genes, 8 2: . doi:10.3390/genes8020071

Author Rebello, Richard J.
Pearson, Richard B.
Hannan, Ross D.
Furic, Luc
Title Therapeutic approaches targeting MYC-Driven prostate cancer
Journal name Genes   Check publisher's open access policy
ISSN 2073-4425
Publication date 2017-02-16
Sub-type Critical review of research, literature review, critical commentary
DOI 10.3390/genes8020071
Open Access Status DOI
Volume 8
Issue 2
Total pages 16
Place of publication Basel, Switzerland
Publisher M D P I AG
Language eng
Subject 1311 Genetics
2716 Genetics (clinical)
Abstract The transcript encoding the proto-oncogene MYC is commonly overexpressed in prostate cancer (PC). MYC protein abundance is also increased in the majority of cases of advanced and metastatic castrate-resistant PC (mCRPC). Accordingly, the MYC-directed transcriptional program directly contributes to PC by upregulating the expression of a number of pro-tumorigenic factors involved in cell growth and proliferation. A key cellular process downstream of MYC activity is the regulation of ribosome biogenesis which sustains tumor growth. MYC activity also cooperates with the dysregulation of the phosphoinositol-3-kinase (PI3K)/AKT/mTOR pathway to promote PC cell survival. Recent advances in the understanding of these interactions through the use of animal models have provided significant insight into the therapeutic efficacy of targeting MYC activity by interfering with its transcriptional program, and indirectly by targeting downstream cellular events linked to MYC transformation potential.
Keyword Mouse models
Prostate cancer
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
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