From raw data to process: the path to a batch or a continuous crystallizer design for ibuprofen

Rashid, Abdur, White, Edward, Howes, Tony, Litster, James and Marziano, Ivan (2017) From raw data to process: the path to a batch or a continuous crystallizer design for ibuprofen. Organic Process Research and Development, 21 2: 187-194. doi:10.1021/acs.oprd.6b00339


Author Rashid, Abdur
White, Edward
Howes, Tony
Litster, James
Marziano, Ivan
Title From raw data to process: the path to a batch or a continuous crystallizer design for ibuprofen
Journal name Organic Process Research and Development   Check publisher's open access policy
ISSN 1520-586X
1083-6160
Publication date 2017-02-17
Sub-type Article (original research)
DOI 10.1021/acs.oprd.6b00339
Open Access Status Not yet assessed
Volume 21
Issue 2
Start page 187
End page 194
Total pages 8
Place of publication Washington, DC, United States
Publisher American Chemical Society
Collection year 2018
Language eng
Abstract To design a crystallizer for producing an active pharmaceutical ingredient (API) of the desired crystal size, it is necessary to know the solubility, the nucleation metastable zone widths (MSZW), the crystal growth rates, and the nucleation rates. These data are available for the popular anti-inflammatory drug ibuprofen crystallized from absolute ethanol and water-ethanol mixtures. Using these data, methods are outlined to design industrial crystallizers to recover ibuprofen crystals. From ethanol, as the solubility increases greatly with temperature, cooling crystallizers can be used industrially. Both seeded batch and continuous designs are considered.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Chemical Engineering Publications
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